Population-genetic and comparative interpopulation studies of the 15 autosomal STR markers in the population living in the Northwest of Iran

IF 1 4区 生物学 Q4 GENETICS & HEREDITY
Saeed Ghadimi Haddadan, Esmaeil Babaei, Mehrdad Setareh
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Abstract

Introduction

Iran, a country in the Middle East, has several ethnic and ethno-religious groups and needs its own ethnic-specific databases for the forensic statistical parameters and allele frequency of STR markers.

Methods

We have investigated 600 unrelated Turk individuals from four northwestern provinces of Iran using the Identifiler™ system (TPOX, FGA, vWA, TH01, CSF1PO, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, and D21S11). Furthermore, STR allelic frequencies were compared to previously population-based data.

Results and conclusion

After Bonferroni correction, deviation from Hardy-Weinberg equilibrium (HWE) was observed in the FGA, TPOX, VWA, and D19S433 loci (P value < 0.05). The combined power of discrimination (CPD) and exclusion (CPE) values for all 15 STR loci were 0.9999999999999999999984 and 0.9999999, respectively. In comparison with Azerbaijani and Turkish populations, there were no significant differences on all STR markers. However, in the Chinese Han population, differences at 13 STR loci were detected. Additionally, comparisons of Fischer genetic distance indices (FST) P-values did not reveal any statistically significant difference between Northwestern Iran, Azerbaijan and Iran (Fars) populations. PCA and PCoA analyses showed that our population was grouped with different populations in different quarters, showing a positive and negative correlation, respectively. In the NJ and UPGMA phylogenetic trees, Iranian populations were grouped together. These results demonstrated that the given set of STR markers can be confidently used for all identification tests in Northwestern Iran.

伊朗西北部人口中 15 个常染色体 STR 标记的人口遗传学和种群间比较研究。
导言:伊朗是一个中东国家,拥有多个民族和民族宗教群体,需要自己的特定民族数据库,用于法医统计参数和 STR 标记的等位基因频率:我们使用 Identifiler™ 系统(TPOX、FGA、vWA、TH01、CSF1PO、D2S1338、D3S1358、D5S818、D7S820、D8S1179、D13S317、D16S539、D18S51、D19S433 和 D21S11)对来自伊朗西北部四个省份的 600 名无亲属关系的土耳其人进行了调查。此外,还将 STR 等位基因频率与以前的人群数据进行了比较:经 Bonferroni 校正后,在 FGA、TPOX、VWA 和 D19S433 位点观察到偏离 Hardy-Weinberg 平衡 (HWE)(P 值 < 0.05)。所有 15 个 STR 位点的综合辨别力(CPD)和排除力(CPE)值分别为 0.99999999999999999984 和 0.999999999。与阿塞拜疆和土耳其人群相比,所有 STR 标记均无显著差异。然而,在中国汉族人群中,13 个 STR 位点存在差异。此外,比较费舍尔遗传距离指数(FST)的 P 值也没有发现伊朗西北部、阿塞拜疆和伊朗(法尔斯)种群之间有任何统计学上的显著差异。PCA 和 PCoA 分析表明,我们的种群与不同地区的不同种群分组,分别呈现出正相关和负相关。在 NJ 和 UPGMA 系统发生树中,伊朗种群被归为一组。这些结果表明,给定的 STR 标记集可以可靠地用于伊朗西北部的所有鉴定测试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Human Genetics
Annals of Human Genetics 生物-遗传学
CiteScore
4.20
自引率
0.00%
发文量
34
审稿时长
3 months
期刊介绍: Annals of Human Genetics publishes material directly concerned with human genetics or the application of scientific principles and techniques to any aspect of human inheritance. Papers that describe work on other species that may be relevant to human genetics will also be considered. Mathematical models should include examples of application to data where possible. Authors are welcome to submit Supporting Information, such as data sets or additional figures or tables, that will not be published in the print edition of the journal, but which will be viewable via the online edition and stored on the website.
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