Holter study of heart rate variability in children and adolescents with long QT syndrome

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Annals of Noninvasive Electrocardiology Pub Date : 2024-06-18 DOI:10.1111/anec.13132

Anna Lundström, Håkan Eliasson, Marcus Karlsson, Urban Wiklund, Annika Rydberg

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引用次数: 0

Abstract

Objectives

This study aimed to retrospectively assess cardiac autonomic activity in children with LQTS, considering genotype, symptoms, sex, age, and beta-blocker therapy (BB) and compare it to healthy controls.

Methods

Heart rate variability (HRV), using power spectrum analysis, was analyzed in 575 Holter recordings from 116 children with LQTS and in 69 healthy children. The data were categorized into four age-groups and four heart rate (HR) ranges.

Results

In LQT1 and LQT2, increasing HR corresponded to significantly lower low (LF) and high frequency (HF) compared to controls. Total power (PTOT) was lower in all LQT1 age-groups compared to controls at HR 120–140 bpm (1–15 years: p < .01; 15–18 years: p = .03). At HR 80–100, LQT1 patients aged 1–10 years had lower HF than LQT2 patients (1–5 years: p = .05; 5–10 years: p = .02), and LQT2 patients aged 15–18 years had lower HF than LQT1 patients (p < .01). Symptomatic patients aged 10–15 years had lower PTOT at HR 100–120 bpm than asymptomatic patients (p = .04). LQT1 girls aged 10–15 and 15–18 years had a lower PTOT (10–15 years: p = .04; 15–18 years: p = .02) than boys.

Conclusion

This study shows a correlation between HR and changes in HRV parameters. At higher HRs, LQTS patients generally had lower HRV values than controls, suggesting an abnormal autonomic response. These results may strengthen the link between physical activity and arrhythmias in LQTS.

Abstract Image

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长 QT 综合征儿童和青少年心率变异性 Holter 研究。

研究目的方法：采用功率谱分析方法，对 116 名 LQTS 儿童和 69 名健康儿童的 575 次 Holter 记录进行心率变异性（HRV）分析。数据分为四个年龄组和四个心率（HR）范围：结果：与对照组相比，在 LQT1 和 LQT2 中，心率增加对应的低频（LF）和高频（HF）明显降低。与对照组相比，在心率为 120-140 bpm 时，所有 LQT1 年龄组的总功率（PTOT）都较低（1-15 岁：P 结论：该研究显示了心率与 LQT1 和 LQT2 之间的相关性：本研究显示了心率与心率变异参数变化之间的相关性。在心率较高时，LQTS 患者的心率变异值普遍低于对照组，这表明自律神经反应异常。这些结果可能会加强体力活动与 LQTS 患者心律失常之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Noninvasive Electrocardiology 医学-心血管系统

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.