Severe COVID-19 in pregnant women: Analysis of placental features and perinatal outcomes.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-06-19 DOI:10.1093/ajcp/aqae072

Gelson Farias Arcos Júnior, Rossana Pulcineli Vieira Francisco, Beatriz Kill, Stela Verzinhasse Peres, Maria Augusta B C Gibelli, Silvia Maria Ibidi, Werther Brunow de Carvalho, Angélica Braz Simões, Maria de Lourdes Brizot, Regina Schultz, Mariana Azevedo Carvalho

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引用次数: 0

Abstract

Objectives: Changes in placental features, such as maternal and fetal vascular malperfusion, are associated with SARS-CoV-2 infection. The anatomopathologic study of the placenta is crucial for understanding pregnancy and fetal complications. To that end, this study aimed to describe placental features and analyze the association between placental findings and perinatal outcomes in a cohort of pregnant women with severe COVID-19.

Methods: This nested study within a prospective cohort study consisted of 121 singleton pregnant women with a diagnosis of severe COVID-19. Placental pathologic findings were described, and the associations between severe COVID-19 and clinical parameters and perinatal outcomes were assessed.

Results: The prevalence of maternal vascular malperfusion was 52.1%, followed by fetal vascular malperfusion at 21.5%, ascending intrauterine infections at 11.6%, and inflammatory lesions at 11.6%. Other lesions were observed in 39.7% of the placentas examined. Inflammatory lesions were an independent factor (P = .042) in 5-minute Apgar scores below 7. Ascending infection was associated with fetal death (P = .027).

Conclusions: Maternal vascular malperfusion was the most prevalent placental feature in patients with severe COVID-19. Chorangiosis is associated with poor perinatal outcomes.

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孕妇重度 COVID-19：胎盘特征和围产期结果分析

目的：胎盘特征的变化，如母体和胎儿血管灌注不良，与 SARS-CoV-2 感染有关。胎盘解剖病理学研究对于了解妊娠和胎儿并发症至关重要。为此，本研究旨在描述严重 COVID-19 孕妇队列中胎盘的特征，并分析胎盘检查结果与围产期结局之间的关联：这项前瞻性队列研究中的嵌套研究包括121名确诊为重度COVID-19的单胎孕妇。研究对胎盘病理结果进行了描述，并评估了重度 COVID-19 与临床参数和围产期结局之间的关联：结果：母体血管灌注不良的发生率为 52.1%，其次是胎儿血管灌注不良（21.5%）、宫内感染（11.6%）和炎性病变（11.6%）。39.7%的受检胎盘存在其他病变。炎性病变是 5 分钟 Apgar 评分低于 7 分的独立因素（P = .042）。上升感染与胎儿死亡有关（P = .027）：结论：母体血管灌注不良是严重COVID-19患者胎盘最常见的特征。结论：在重度COVID-19患者中，母体血管灌注不良是最常见的胎盘特征，脉管扩张与围产期不良预后有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464