Method to determine envelope density for roller compacted ribbons by solid displacement of glass microspheres

IF 4.5 2区工程技术 Q2 ENGINEERING, CHEMICAL

Powder Technology Pub Date : 2024-06-16 DOI:10.1016/j.powtec.2024.120014

Nikita Marinko , Ivona Sedlářová , Simona Römerová , Michaela Gajdošová , Vít Zvoníček , Petr Zámostný

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引用次数: 0

Abstract

The envelope density of the roll-compacted ribbon is a widely accepted physical property that serves as a criterion for the transferability of dry granulation processes. Existing methods of obtaining ribbon density data have drawbacks in their reliability and availability at production facilities. A novel method is proposed in this paper and the performance thereof is compared to other established techniques. A pilot study was conducted on several roller compactors to prepare various batches of ribbons under different process parameters using model and real formulations from the industry. The presented method measures the envelope volume of roll-compacted ribbons by solid volume displacement of glass microspheres. The solid displacement method for measuring envelope density is as precise as mercury porosimetry, provided that the ribbon quality is adequate, even in the presence of minor structural failures, it is nondestructive allowing sample reuse, and it is scalable to larger ribbon sizes.

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通过玻璃微球的固体位移确定辊压带包络密度的方法

辊压带的包络密度是一种广为接受的物理特性，是干法造粒工艺可转让性的标准。现有的获取色带密度数据的方法在可靠性和生产设施的可用性方面存在缺陷。本文提出了一种新方法，并将其性能与其他成熟技术进行了比较。我们在几台辊式压制机上进行了试验研究，利用行业中的模型和实际配方，在不同的工艺参数下制备了不同批次的色带。所介绍的方法通过玻璃微球的固体体积位移来测量辊式压制带的包络体积。固体位移法测量包络密度的精确度不亚于汞孔测量法，前提是色带的质量足够好，即使存在轻微的结构故障，这种方法是无损的，可以重复使用样品，而且可以扩展到更大尺寸的色带。

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.