Development and characterization of a Fricke gel dosimeter for precise measurement in low-dose photon fields

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Seyed Amir Saeedi-Sini, S. Sina, M. Sadeghi, Ebrahim Farajzadeh
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Abstract

In the field of radiation medicine, particularly within radiotherapy applications, radiochromic chemical dosimeters are indispensable tools for dose measurement. This study focuses on the novel development of a radiochromic dosimeter tailored for the precise detection of low-dose radiation, aiming to construct a dosimeter with tissue-equivalent properties suitable for accurately measuring low to medium radiation doses. Utilizing ferrous xylenol orange gel (FXG), we developed two tissue-equivalent dosimeter formulations based on gelatin and polyvinyl alcohol (PVA). Our findings demonstrate that the gelatin-based FXG dosimeter exhibits a robust linear dose-response relationship, facilitating precise dose measurements in the range of 50 to 5000 mGy. Conversely, the PVA-based FXG dosimeter proved effective for dose measurements within a narrower range of 600 to 5000 mGy. Notably, the gelatin-based dosimeter's performance underscores its potential as a versatile tool in radiation detection, promising significant benefits for both medical and industrial applications. This research confirms the efficacy of the Fricke dosimeter gel, demonstrating its linear response across a dose range of 0.05 to 5 Gy, thus establishing a foundation for further advancements in accurate and reliable low-dose radiation monitoring.
用于低剂量光子场精确测量的弗里克凝胶剂量计的开发和特性分析
在放射医学领域,特别是在放射治疗应用中,放射变色化学剂量计是剂量测量不可或缺的工具。本研究的重点是为精确检测低剂量辐射而量身定制的放射变色剂量计的新型开发,旨在构建一种具有组织等效特性的剂量计,适用于精确测量中低剂量辐射剂量。利用二甲酚亚铁橙凝胶(FXG),我们开发了两种基于明胶和聚乙烯醇(PVA)的组织等效剂量计配方。我们的研究结果表明,基于明胶的 FXG 剂量计表现出稳健的线性剂量-反应关系,有助于在 50 至 5000 mGy 范围内进行精确的剂量测量。相反,基于 PVA 的 FXG 剂量计则可在 600 至 5000 mGy 的较窄范围内进行有效的剂量测量。值得注意的是,明胶基剂量计的性能突出了其作为辐射检测多功能工具的潜力,有望为医疗和工业应用带来显著效益。这项研究证实了弗里克剂量计凝胶的功效,证明了它在 0.05 至 5 Gy 剂量范围内的线性响应,从而为进一步推进准确可靠的低剂量辐射监测奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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