{"title":"Diversity of SARS-CoV-2 genome among various strains identified in Lucknow, Uttar Pradesh","authors":"Biswajit Sahoo , Pramod Kumar Maurya , Ratnesh Kumar Tripathi , Jyotsna Agarwal , Swasti Tiwari","doi":"10.1016/j.humgen.2024.201304","DOIUrl":null,"url":null,"abstract":"<div><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a significant challenge worldwide. Rapid genome sequencing of SARS-CoV-2 is going on across the globe to detect mutations and genomic modifications in SARS-CoV-2. In this study, we have sequenced 23 SARS-CoV-2-positive samples collected during the first pandemic from the state of Uttar Pradesh, India. We observed a range of already reported mutations (2−22), including D614G, L452R, Q613H, Q677H, and T1027I in the S gene; S194L in the N gene; and Q57H, L106F, and T175I in the ORF3. A few unreported mutations, such as P309S in the ORF1ab gene, T379I in the N gene, and L52F and V77I in the ORF3a gene, were also detected. Phylogenetic genome analysis showed similarity with other SARS-CoV-2 viruses reported from Uttar Pradesh. The observed mutations may be associated with SARS-CoV-2 virus pathogenicity or disease severity.</p></div>","PeriodicalId":29686,"journal":{"name":"Human Gene","volume":"41 ","pages":"Article 201304"},"PeriodicalIF":0.5000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Gene","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773044124000482","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a significant challenge worldwide. Rapid genome sequencing of SARS-CoV-2 is going on across the globe to detect mutations and genomic modifications in SARS-CoV-2. In this study, we have sequenced 23 SARS-CoV-2-positive samples collected during the first pandemic from the state of Uttar Pradesh, India. We observed a range of already reported mutations (2−22), including D614G, L452R, Q613H, Q677H, and T1027I in the S gene; S194L in the N gene; and Q57H, L106F, and T175I in the ORF3. A few unreported mutations, such as P309S in the ORF1ab gene, T379I in the N gene, and L52F and V77I in the ORF3a gene, were also detected. Phylogenetic genome analysis showed similarity with other SARS-CoV-2 viruses reported from Uttar Pradesh. The observed mutations may be associated with SARS-CoV-2 virus pathogenicity or disease severity.
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