Epidemiology, prognostic factors, and treatment of head and neck mucoepidermoid carcinoma: Analysis of the surveillance, epidemiology, and end results database

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology Pub Date : 2024-06-08 DOI:10.1016/j.bjorl.2024.101450

{"title":"Epidemiology, prognostic factors, and treatment of head and neck mucoepidermoid carcinoma: Analysis of the surveillance, epidemiology, and end results database","authors":"","doi":"10.1016/j.bjorl.2024.101450","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>To investigate prognostic factors in patients with head and neck Mucoepidermoid Carcinoma (MEC), especially the impact of treatment modalities on survival.</p></div><div><h3>Methods</h3><p>Patients with primary head and neck MEC between 2000 and 2015 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Prognostic factors related to Overall Survival (OS) and Cancer-Specific Survival (CSS), as well as the impact of treatments, were evaluated by multivariable Cox regression analysis.</p></div><div><h3>Results</h3><p>We identified 2692 patients diagnosed with head and neck MEC, of whom 1397 (51.89%) had a parotid gland primary, 569 (22.14%) died, and 341 (12.67%) died of MEC. Older age (≥53 years), males, unmarried, lower income, tumor site in other head and neck areas, higher tumor grade, larger tumor size, and higher stage were related to poorer OS and CSS. Patients who did not undergo surgery (HR=3.20, 95% CI 2.45‒4.18) had worse OS, while no significant difference was detected between partial and total organ excision on patients’ OS (<em>p</em>      =0.218). For CSS, the corresponding results were consistent with OS.</p></div><div><h3>Conclusion</h3><p>Surgical resection only may be a better survival option for head and neck MEC.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 5","pages":"Article 101450"},"PeriodicalIF":1.7000,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S180886942400065X/pdfft?md5=e8732520f2d18e4ad87c4c70f7e13f14&pid=1-s2.0-S180886942400065X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brazilian Journal of Otorhinolaryngology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S180886942400065X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

To investigate prognostic factors in patients with head and neck Mucoepidermoid Carcinoma (MEC), especially the impact of treatment modalities on survival.

Methods

Patients with primary head and neck MEC between 2000 and 2015 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Prognostic factors related to Overall Survival (OS) and Cancer-Specific Survival (CSS), as well as the impact of treatments, were evaluated by multivariable Cox regression analysis.

Results

We identified 2692 patients diagnosed with head and neck MEC, of whom 1397 (51.89%) had a parotid gland primary, 569 (22.14%) died, and 341 (12.67%) died of MEC. Older age (≥53 years), males, unmarried, lower income, tumor site in other head and neck areas, higher tumor grade, larger tumor size, and higher stage were related to poorer OS and CSS. Patients who did not undergo surgery (HR = 3.20, 95% CI 2.45‒4.18) had worse OS, while no significant difference was detected between partial and total organ excision on patients’ OS (p = 0.729). For combination therapy, patients who received radiotherapy only (HR = 3.21, 95% CI 2.27–4.53) or no surgery and no radiotherapy (HR = 2.59, 95% CI 1.83–3.67) were correlated with worse OS (vs. surgery only), but no significant difference was detected between surgery only and surgery combined with radiotherapy on patients’ OS (p = 0.218). For CSS, the corresponding results were consistent with OS.

Conclusion

Surgical resection only may be a better survival option for head and neck MEC.

查看原文本刊更多论文

头颈部粘液表皮样癌的流行病学、预后因素和治疗：监测、流行病学和最终结果数据库分析

目的研究头颈部黏液表皮样癌（MEC）患者的预后因素，尤其是治疗方式对生存期的影响。方法从监测、流行病学和最终结果（SEER）数据库中获取 2000 年至 2015 年间原发性头颈部黏液表皮样癌患者的资料。结果我们发现了2692名确诊为头颈部MEC的患者，其中1397人（51.89%）原发于腮腺，569人（22.14%）死亡，341人（12.67%）死于MEC。年龄较大（≥53 岁）、男性、未婚、收入较低、肿瘤部位在其他头颈部、肿瘤分级较高、肿瘤体积较大和分期较高与较差的 OS 和 CSS 有关。未接受手术的患者（HR = 3.20，95% CI 2.45-4.18）的OS较差，而部分器官切除和全器官切除对患者的OS无显著差异（P = 0.729）。就联合治疗而言，只接受放疗（HR = 3.21，95% CI 2.27-4.53）或不接受手术和放疗（HR = 2.59，95% CI 1.83-3.67）的患者OS较差（与只接受手术相比），但只接受手术和手术联合放疗对患者OS的影响无明显差异（P = 0.218）。结论仅进行手术切除可能是头颈部 MEC 患者更好的生存选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brazilian Journal of Otorhinolaryngology OTORHINOLARYNGOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

205

审稿时长

4-8 weeks

期刊介绍： Brazilian Journal of Otorhinolaryngology publishes original contributions in otolaryngology and the associated areas (cranio-maxillo-facial surgery and phoniatrics). The aim of this journal is the national and international divulgation of the scientific production interesting to the otolaryngology, as well as the discussion, in editorials, of subjects of scientific, academic and professional relevance. The Brazilian Journal of Otorhinolaryngology is born from the Revista Brasileira de Otorrinolaringologia, of which it is the English version, created and indexed by MEDLINE in 2005. It is the official scientific publication of the Brazilian Association of Otolaryngology and Cervicofacial Surgery. Its abbreviated title is Braz J Otorhinolaryngol., which should be used in bibliographies, footnotes and bibliographical references and strips.