Antibacterial resistance and the cost of affecting demand: The case of UK antibiotics

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-01 DOI:10.1016/j.ijindorg.2024.103082

Farasat A.S. Bokhari , Franco Mariuzzo , Weijie Yan

引用次数: 0

Abstract

Consumption of broad-spectrum antibiotics is associated with rising antimicrobial resistance (AMR) levels. The use of broad-spectrum drugs, particularly of cephalosporins, quinolones, and co-amoxiclav contributes the most to the rise in AMR. We use aggregate sales data on antibiotics from the UK to estimate structural demand models and reveal drug substitution patterns. We then simulate alternative tax schemes to evaluate the effectiveness of shifting demand from broad- to narrow-spectrum drugs. Our estimates suggest that these policies can be highly effective in demand management and come at a relatively low cost regarding changes in consumer and producer surplus.

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抗菌药耐药性和影响需求的成本：英国抗生素案例

广谱抗生素的使用与抗菌素耐药性（AMR）水平的上升有关。广谱药物的使用，尤其是头孢菌素类、喹诺酮类和联合阿莫西林类药物的使用，是导致 AMR 上升的主要原因。我们利用英国抗生素的总体销售数据来估算结构性需求模型并揭示药物替代模式。然后，我们模拟了替代税收方案，以评估将需求从广谱药物转向窄谱药物的效果。我们的估算结果表明，这些政策在需求管理方面非常有效，而且在消费者和生产者剩余的变化方面成本相对较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.