Deaths and major cardiovascular events in patients with lymphoma: Analysis from a French nationwide hospitalization database

IF 2.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Archives of Cardiovascular Diseases Pub Date : 2024-08-01 DOI:10.1016/j.acvd.2024.05.117

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引用次数: 0

Abstract

Background

There are few data assessing the risk of death and cardiovascular events in patients with lymphoma.

Aim

Using a nationwide hospitalization database, we aimed to address cardiovascular outcomes in patients with lymphoma.

Methods

From 01 January to 31 December 2013, 3,381,472 adults were hospitalized in French hospitals; 22,544 of these patients had a lymphoma. The outcome analysis (all-cause or cardiovascular death, myocardial infarction, ischaemic stroke, bleedings, new-onset heart failure and new-onset atrial fibrillation) was performed over a 5-year follow-up period. Each patient with lymphoma was matched with a patient without a lymphoma or other cancer (1:1). A competing risk analysis was also performed.

Results

After adjustment on all risk factors, cardiovascular and non-cardiovascular co-morbidities, the subdistribution hazard ratios for all-cause death, major bleeding, intracranial bleeding, new-onset heart failure and new-onset atrial fibrillation were higher in patients with lymphoma; conversely, the subdistribution hazard ratios for cardiovascular death, myocardial infarction and ischaemic stroke were lower in patients with lymphoma. In the matched analysis, the risk of all-cause death (subdistribution hazard ratio 1.936, 95% confidence interval 1.881–1.992) and major bleeding (subdistribution hazard ratio 1.117, 95% confidence interval 1.049–1.188) remained higher in patients with lymphoma.

Conclusion

In this large nationwide cohort study, patients with lymphoma had a higher incidence of all-cause death and major bleeding.

Abstract Image

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淋巴瘤患者的死亡和主要心血管事件：法国全国住院数据库分析

背景评估淋巴瘤患者死亡和心血管事件风险的数据很少。方法2013年1月1日至12月31日，3,381,472名成年人在法国医院住院治疗，其中22,544名患者患有淋巴瘤。结果分析（全因或心血管死亡、心肌梗死、缺血性中风、出血、新发心力衰竭和新发心房颤动）在5年随访期内进行。每位淋巴瘤患者都与未患淋巴瘤或其他癌症的患者进行了配对（1:1）。结果在对所有风险因素、心血管和非心血管并发症进行调整后，淋巴瘤患者的全因死亡、大出血、颅内出血、新发心力衰竭和新发心房颤动的亚分布危险比率较高；相反，淋巴瘤患者的心血管死亡、心肌梗死和缺血性中风的亚分布危险比率较低。在匹配分析中，淋巴瘤患者的全因死亡风险（亚分布危险比 1.936，95% 置信区间 1.881-1.992）和大出血风险（亚分布危险比 1.117，95% 置信区间 1.049-1.188）仍然较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Cardiovascular Diseases 医学-心血管系统

CiteScore

4.40

自引率

6.70%

发文量

审稿时长

34 days

期刊介绍： The Journal publishes original peer-reviewed clinical and research articles, epidemiological studies, new methodological clinical approaches, review articles and editorials. Topics covered include coronary artery and valve diseases, interventional and pediatric cardiology, cardiovascular surgery, cardiomyopathy and heart failure, arrhythmias and stimulation, cardiovascular imaging, vascular medicine and hypertension, epidemiology and risk factors, and large multicenter studies. Archives of Cardiovascular Diseases also publishes abstracts of papers presented at the annual sessions of the Journées Européennes de la Société Française de Cardiologie and the guidelines edited by the French Society of Cardiology.