Impacto de la inmunización con nirsevimab en las infecciones por VRS atendidas en urgencias pediátricas: primeros resultados en un hospital terciario de Madrid

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2024-08-01 DOI:10.1016/j.eimc.2024.04.010

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引用次数: 0

Abstract

Introduction

Human respiratory syncytial virus (RSV) is the most commonly identified virus associated with lower respiratory tract infections. The monoclonal antibody nirsevimab immunization campaign began in our country in October 2023.

Methods

This study was conducted in the Pediatric Emergency Department (PED) of a tertiary care center in Madrid, Spain. The aim was to compare PED visits of patients eligible for immunization with nirsevimab who attended between weeks 40 and 52 of 2022 and 2023 and who had a confirmed diagnosis of RSV infection.

Results

During the study period, 264 out of 765 patients with confirmed RSV infection who attended the PED were eligible for immunization with nirsevimab and were selected for our analysis. The PED attendance was 80.3% in 2022 and 19.7% in 2023. The number of RSV-positive cases increased from week 42 in both analyzed periods, with a peak of maximum incidence between weeks 46 and 48. In 2022, the morphology of the case curve in the group of children eligible for immunization was similar to the overall curve. However, in 2023, we did not observe a similar increase in cases among patients eligible for immunization.

Conclusion

Immunization with nirsevimab during the 2023 RSV epidemic season had a beneficial effect, reducing the number of PED consultations for RSV infection.

查看原文本刊更多论文

nirsevimab 免疫接种对儿科急诊室 RSV 感染的影响：马德里一家三级医院的初步结果。

导言人类呼吸道合胞病毒（RSV）是与下呼吸道感染相关的最常见病毒。本研究在西班牙马德里一家三级医疗中心的儿科急诊科（PED）进行。目的是比较 2022 年第 40 周至 2023 年第 52 周期间符合接种 nirsevimab 免疫接种条件且确诊感染 RSV 的患者在 PED 就诊的情况。结果在研究期间，765 名确诊感染 RSV 的患者中有 264 名在 PED 就诊，符合接种 nirsevimab 免疫接种条件，并被选中进行分析。2022年和2023年的PED就诊率分别为80.3%和19.7%。在两个分析期间，RSV 阳性病例的数量从第 42 周开始增加，在第 46 周和第 48 周之间达到最高峰。2022 年，符合免疫条件的儿童群体的病例曲线形态与总体曲线相似。结论在2023年RSV流行季节使用尼舍单抗免疫接种产生了有益的效果，减少了因RSV感染而到PED就诊的人数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.