Association between frozen embryo transfer and childhood allergy: a retrospective cohort study

IF 3.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Reproductive biomedicine online Pub Date : 2024-06-09 DOI:10.1016/j.rbmo.2024.104320

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引用次数: 0

Abstract

Research question

Does frozen embryo transfer (FET) increase the risk of allergic diseases in offspring?

Design

This study followed up 653 singleton children: 166 born through FET and 487 born through natural conception. Demographic characteristics, perinatal information and allergic diseases of children and their parents were collected through clinical medical systems and questionnaires. Among these 653 children, allergen-specific immunoglobulin E (IgE) testing was performed using peripheral blood samples collected from 207 children: 145 in the FET group and 62 in the natural conception group. The prevalence of allergic diseases and positive rates of allergen-specific IgE testing were compared between the two groups with adjustments for confounding factors.

Results

The prevalence of food allergy was significantly higher in children born through FET compared with children born through natural conception (adjusted OR = 3.154, 95% CI 1.895–5.250; P < 0.001). In addition, positive rates of food allergen sensitization were higher in children in the FET group compared with children in the natural conception group (adjusted OR = 5.769, 95% CI 2.859–11.751, P < 0.001). Children in the FET group had a higher positive sensitization rate to at least one allergen compared with children in the natural conception group (adjusted OR = 3.127, 95% CI 1.640–5.961, P < 0.001). No association was observed between FET and other allergic diseases, including asthma (P = 0.136), atopic dermatitis (P = 0.130) and allergic rhinitis (P = 0.922). Allergen sensitization IgE testing indicated no differences between the two groups in terms of positive sensitization rates of other common allergens, including animal and insect allergens (P = 0.627), inhaled outdoor allergens (P = 0.915) and inhaled outdoor allergens (P = 0.544).

Conclusion

This study suggests that children born through FET have increased risk of developing food allergy in early childhood.

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冷冻胚胎移植与儿童过敏症之间的关系：一项回顾性队列研究

研究问题冷冻胚胎移植（FET）是否会增加后代患过敏性疾病的风险？设计这项研究对 653 名单胎儿童进行了跟踪调查：其中 166 名是通过冷冻胚胎移植出生的，487 名是通过自然受孕出生的。通过临床医疗系统和问卷调查收集了儿童及其父母的人口统计学特征、围产期信息和过敏性疾病。在这 653 名儿童中，使用从 207 名儿童采集的外周血样本对过敏原特异性免疫球蛋白 E (IgE) 进行了检测，其中 145 名儿童是通过 FET 出生的，62 名儿童是通过自然受孕出生的。结果与自然受孕的儿童相比，经 FET 出生的儿童中食物过敏的患病率明显更高（调整后 OR = 3.154，95% CI 1.895-5.250；P <0.001）。此外，与自然受孕组儿童相比，人工授精组儿童的食物过敏原致敏阳性率更高（调整后 OR = 5.769，95% CI 2.859-11.751，P <0.001）。与自然受孕组的儿童相比，FET 组的儿童对至少一种过敏原的阳性致敏率更高（调整后 OR = 3.127，95% CI 1.640-5.961，P < 0.001）。FET 与其他过敏性疾病，包括哮喘（P = 0.136）、特应性皮炎（P = 0.130）和过敏性鼻炎（P = 0.922）之间没有关联。过敏原致敏 IgE 测试表明，两组儿童对其他常见过敏原的致敏率没有差异，包括动物和昆虫过敏原（P = 0.627）、吸入性室外过敏原（P = 0.915）和吸入性室外过敏原（P = 0.544）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive biomedicine online 医学-妇产科学

CiteScore

7.20

自引率

7.50%

发文量

391

审稿时长

50 days

期刊介绍： Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.