Increased frequency of microalbuminuria in patients with type 3 autoimmune polyglandular syndrome (APS) compared to isolated autoimmune type 1 diabetes mellitus: A real-life study

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-07-01 DOI:10.1016/j.diabres.2024.111746

Stefano Radellini , Enrica Vigneri , Ornella Ferreri , Piero Luigi Almasio , Giuseppe Pizzolanti , Carla Giordano , Valentina Guarnotta

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Abstract

Aim of the study

The primary aim of the study was to evaluate the differences in metabolic control and chronic microvascular complications in patients with type 3 autoimmune polyglandular syndrome (APS3), compared to type 1 diabetes mellitus (T1DM) alone. Secondary aims were to evaluate the age of autoimmune thyroid disease (AIT) onset and the effects of levothyroxine treatment on metabolic control in patients with APS3.

Material and methods

We retrospectively reviewed 276 patients with T1DM alone and 214 patients with APS3 and evaluated clinical and metabolic parameters and microvascular complications.

Results

Patients with T1DM showed a longer duration of diabetes (p = 0.001) and lower age of diabetes onset (p = 0.020) compared to patients with APS3. Female gender (p = 0.001) and microalbuminuria (p = 0.006) were significantly more frequent in patients with APS3 compared to T1DM. In addition, patients with APS3 showed higher AIT onset frequency in the 16–30 quartile age-range. Furthermore, APS3 patients treated with levothyroxine showed significantly better HbA1c values than non-treated patients (p = 0.001).

Conclusions

We found that patients with APS3 showed positive microalbuminuria, earlier than T1DM. Patients with APS3 showed higher frequency of AIT age of onset in the 16–30 age-range and those treated with levothyroxine had better metabolic control, than untreated ones.

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与孤立的自身免疫性 1 型糖尿病相比，3 型自身免疫性多腺体综合征 (APS) 患者出现微量白蛋白尿的频率更高：一项真实生活研究

研究目的该研究的主要目的是评估3型自身免疫性多腺体综合征（APS3）患者与单纯1型糖尿病（T1DM）患者在代谢控制和慢性微血管并发症方面的差异。次要目的是评估自身免疫性甲状腺疾病（AIT）的发病年龄以及左甲状腺素治疗对APS3患者代谢控制的影响。材料与方法我们回顾性研究了276例单纯T1DM患者和214例APS3患者，并评估了临床和代谢指标以及微血管并发症。与 T1DM 患者相比，APS3 患者中女性（p = 0.001）和微量白蛋白尿（p = 0.006）的发病率明显更高。此外，APS3 患者在 16-30 四分位年龄段的 AIT 发病频率较高。此外，接受左甲状腺素治疗的 APS3 患者的 HbA1c 值明显优于未接受治疗的患者（p = 0.001）。APS3患者的AIT发病年龄在16-30岁之间的频率较高，与未接受治疗的患者相比，接受左甲状腺素治疗的患者具有更好的代谢控制能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.