Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing

Q1 Medicine
Xiuhong Huang , Meimei Fu , Min Lu , Xiaoxian Wu , Weiqian David Hong , Xiaoying Wang , Panpan Wu , Keke Wu
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Abstract

Current treatments for diabetic wounds have some curative effect, but the process is complicated and lack user-friendly wound dressings. Nanozymes have gained significant attention for wound healing due to their striking merits. Herein, we have developed a novel sprayable tannin acid-cobalt coordination nanozyme (TACo) for diabetic wound healing. TACo nanozyme offers a convenient and efficient methods by spraying directly onto wounds surface, reducing infection risk by avoiding direct contact. Notably, its antioxidant properties contribute to scavenging the reactive oxygen species (ROS), alleviating oxidative stress and inflammation of wound microenvironment. Additionally, TACo nanozyme could promote cell survival and multiplication, which is crucial for the wound healing process. Importantly, TACo nanozyme facilitates angiogenesis by enhancing cell viability, migration, and tube formation. The unique coordination between metal and phenolic components confers pH-responsive cobalt ion and TA release properties, avoiding secondary damage during the wound cleaning. This unique composition seamlessly integrates photothermal antibacterial therapy, inflammatory microenvironment management, supporting for angiogenesis, and effective promotion of extracellular matrix production sequentially by harnessing the acidic pH environment of diabetic wounds. In conclusion, the development of a sprayable TACo nanozyme presents a promising therapeutic approach for the treatment of diabetic wounds, addressing the complexities of current treatments and providing a user-friendly application method.

Abstract Image

基于多酚的光热纳米颗粒具有可喷洒功能,可自我调节微环境以加速糖尿病伤口愈合
目前对糖尿病创面的治疗虽有一定疗效,但治疗过程复杂且缺乏方便使用的创面敷料。纳米酶由于其显著的优点,在伤口愈合方面受到了极大的关注。在此,我们开发了一种用于糖尿病伤口愈合的新型喷雾单宁酸钴配位纳米酶(TACo)。TACo纳米酶提供了方便和有效的方法,直接喷洒在伤口表面,避免直接接触,降低感染风险。值得注意的是,其抗氧化特性有助于清除活性氧(ROS),减轻伤口微环境的氧化应激和炎症。此外,TACo纳米酶可以促进细胞存活和增殖,这对伤口愈合过程至关重要。重要的是,TACo纳米酶通过增强细胞活力、迁移和管形成来促进血管生成。金属和酚类成分之间的独特配合赋予了ph响应钴离子和TA释放特性,避免了伤口清洁过程中的二次损伤。这种独特的成分无缝集成光热抗菌治疗,炎症微环境管理,支持血管生成,并通过利用糖尿病伤口的酸性pH环境有效促进细胞外基质的生产。总之,一种可喷雾的TACo纳米酶的开发为糖尿病伤口的治疗提供了一种有前景的治疗方法,解决了当前治疗的复杂性,并提供了一种用户友好的应用方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Engineered regeneration
Engineered regeneration Biomaterials, Medicine and Dentistry (General), Biotechnology, Biomedical Engineering
CiteScore
22.90
自引率
0.00%
发文量
0
审稿时长
33 days
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