Joscha Boehm , Daniel Moser , Peter Neugebauer , Jakob Rehrl , Peter Poechlauer , Dirk Kirschneck , Martin Horn , Martin Steinberger , Stephan Sacher
{"title":"A modeling and control framework for extraction processes","authors":"Joscha Boehm , Daniel Moser , Peter Neugebauer , Jakob Rehrl , Peter Poechlauer , Dirk Kirschneck , Martin Horn , Martin Steinberger , Stephan Sacher","doi":"10.1016/j.ces.2024.120384","DOIUrl":null,"url":null,"abstract":"<div><p>Many continuously operated pharmaceutical process routes have been presented recently. Most of these cover the synthesis of the active pharmaceutical ingredient (API) or solid dosage processing. However, the API purification is also gaining attraction. One widespread and waste-intensive unit operation for purification is the liquid–liquid-extraction (LLE). In continuous manufacturing active process control is required, especially for fast processes. Control concepts must be able to react on product quality deviations caused by disturbances or inadequate process settings in real-time. In this study different control concepts for LLE were developed for an extraction column and a multistage extraction. A universally applicable process model was derived and parametrized. The impact of several control concepts including different real-time measurements was evaluated in simulation for both LLE process routes. The results show that simulation tools based on proper process models can support the selection of the most efficient process route and of suitable control concepts.</p></div>","PeriodicalId":271,"journal":{"name":"Chemical Engineering Science","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering Science","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0009250924006845","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Many continuously operated pharmaceutical process routes have been presented recently. Most of these cover the synthesis of the active pharmaceutical ingredient (API) or solid dosage processing. However, the API purification is also gaining attraction. One widespread and waste-intensive unit operation for purification is the liquid–liquid-extraction (LLE). In continuous manufacturing active process control is required, especially for fast processes. Control concepts must be able to react on product quality deviations caused by disturbances or inadequate process settings in real-time. In this study different control concepts for LLE were developed for an extraction column and a multistage extraction. A universally applicable process model was derived and parametrized. The impact of several control concepts including different real-time measurements was evaluated in simulation for both LLE process routes. The results show that simulation tools based on proper process models can support the selection of the most efficient process route and of suitable control concepts.
最近出现了许多连续运行的制药工艺路线。其中大部分涉及活性药物成分 (API) 的合成或固体制剂的加工。然而,原料药的提纯也越来越有吸引力。液-液萃取(LLE)是一种广泛应用且废物密集型的纯化单元操作。在连续生产过程中,尤其是在快速生产过程中,需要进行积极的过程控制。控制概念必须能够对由于干扰或工艺设置不当造成的产品质量偏差做出实时反应。本研究针对萃取柱和多级萃取开发了不同的 LLE 控制概念。得出了一个普遍适用的工艺模型,并对其进行了参数化。在模拟中评估了几种控制概念(包括不同的实时测量)对两种 LLE 工艺路线的影响。结果表明,基于适当工艺模型的模拟工具有助于选择最有效的工艺路线和合适的控制概念。
期刊介绍:
Chemical engineering enables the transformation of natural resources and energy into useful products for society. It draws on and applies natural sciences, mathematics and economics, and has developed fundamental engineering science that underpins the discipline.
Chemical Engineering Science (CES) has been publishing papers on the fundamentals of chemical engineering since 1951. CES is the platform where the most significant advances in the discipline have ever since been published. Chemical Engineering Science has accompanied and sustained chemical engineering through its development into the vibrant and broad scientific discipline it is today.