Epigenetic modifications of gonadotropin receptors can regulate follicular development

IF 2.2 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Reproduction Science Pub Date : 2024-06-13 DOI:10.1016/j.anireprosci.2024.107534

引用次数: 0

Abstract

The spatiotemporal transcription of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) are crucial events for follicular development. However, their regulatory mechanisms are unclear. DNA methylation and histone acetylation are the main epigenetic modifications, and play important roles in transcriptional expression, which regulate cell responses including cell proliferation, senescence and apoptosis. This review will discuss the dynamic epigenetic modifications of FSHR and LHCGR that occur during the process of follicular development and their response to gonadotropins. In addition, some alteration patterns that occur during these epigenetic modifications, as well as their retrospect retrotransposons, which regulate the gene expression levels of FSHR and LHCGR will be discussed.

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促性腺激素受体的表观遗传修饰可调控卵泡发育

卵泡刺激素受体（FSHR）和黄体生成素/人绒毛膜促性腺激素受体（LHCGR）的时空转录是卵泡发育的关键事件。然而，它们的调控机制尚不清楚。DNA 甲基化和组蛋白乙酰化是主要的表观遗传修饰，在转录表达中发挥着重要作用，可调控细胞反应，包括细胞增殖、衰老和凋亡。本综述将讨论 FSHR 和 LHCGR 在卵泡发育过程中发生的动态表观遗传修饰及其对促性腺激素的反应。此外，还将讨论在这些表观遗传修饰过程中发生的一些改变模式，以及它们的逆转录转座子，这些逆转录转座子可调控 FSHR 和 LHCGR 的基因表达水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animal Reproduction Science 农林科学-奶制品与动物科学

CiteScore

4.50

自引率

9.10%

发文量

136

审稿时长

54 days

期刊介绍： Animal Reproduction Science publishes results from studies relating to reproduction and fertility in animals. This includes both fundamental research and applied studies, including management practices that increase our understanding of the biology and manipulation of reproduction. Manuscripts should go into depth in the mechanisms involved in the research reported, rather than a give a mere description of findings. The focus is on animals that are useful to humans including food- and fibre-producing; companion/recreational; captive; and endangered species including zoo animals, but excluding laboratory animals unless the results of the study provide new information that impacts the basic understanding of the biology or manipulation of reproduction. The journal''s scope includes the study of reproductive physiology and endocrinology, reproductive cycles, natural and artificial control of reproduction, preservation and use of gametes and embryos, pregnancy and parturition, infertility and sterility, diagnostic and therapeutic techniques. The Editorial Board of Animal Reproduction Science has decided not to publish papers in which there is an exclusive examination of the in vitro development of oocytes and embryos; however, there will be consideration of papers that include in vitro studies where the source of the oocytes and/or development of the embryos beyond the blastocyst stage is part of the experimental design.