Effect of concentrated exposure and response prevention on symptoms of insomnia

IF 1.9 4区医学 Q3 PSYCHIATRY

Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-07-01 DOI:10.1016/j.jocrd.2024.100891

Nils Eivind Holth Landrø , Sigurd Holmen Pryser , Kristen Hagen , Bjarne Hansen , Gerd Kvale , Stian Solem

{"title":"Effect of concentrated exposure and response prevention on symptoms of insomnia","authors":"Nils Eivind Holth Landrø , Sigurd Holmen Pryser , Kristen Hagen , Bjarne Hansen , Gerd Kvale , Stian Solem","doi":"10.1016/j.jocrd.2024.100891","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Insomnia symptoms are prevalent among patients with obsessive-compulsive disorder (OCD). This study involved secondary analyses from a previous randomized controlled trial testing if <span>d</span>-Cycloserine (DCS) augmented the effects of the Bergen 4-day treatment (B4DT) for OCD. In this study, the effects of the B4DT on sleep difficulties in a sample of difficult-to-treat OCD were explored.</p></div><div><h3>Methods</h3><p>The three groups received B4DT with either a placebo, 100 mg, or 250 mg of DCS. Patients (<em>N</em> = 163) had either not responded or relapsed after previous exposure-based treatment for OCD.</p></div><div><h3>Results</h3><p>The results showed a small, but robust treatment effect on insomnia symptoms (<em>d</em> = 0.37), maintained at 3-month follow-up (<em>d</em> = 0.38), and 12-month follow-up (<em>d</em> = 0.23). No significant differences between the groups receiving DCS or placebo were found. Insomnia did not affect OCD-treatment outcome.</p></div><div><h3>Discussion</h3><p>This study showed that OCD treatment is associated with some improvement in insomnia symptoms. Comorbid insomnia and DCS did not moderate treatment outcome. Patients with OCD and comorbid insomnia should be considered for specific insomnia treatment.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":"42 ","pages":"Article 100891"},"PeriodicalIF":1.9000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211364924000356/pdfft?md5=2e087f2e4fae937ffe1e9b2ab43cf1f7&pid=1-s2.0-S2211364924000356-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obsessive-Compulsive and Related Disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211364924000356","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Insomnia symptoms are prevalent among patients with obsessive-compulsive disorder (OCD). This study involved secondary analyses from a previous randomized controlled trial testing if d-Cycloserine (DCS) augmented the effects of the Bergen 4-day treatment (B4DT) for OCD. In this study, the effects of the B4DT on sleep difficulties in a sample of difficult-to-treat OCD were explored.

Methods

The three groups received B4DT with either a placebo, 100 mg, or 250 mg of DCS. Patients (N = 163) had either not responded or relapsed after previous exposure-based treatment for OCD.

Results

The results showed a small, but robust treatment effect on insomnia symptoms (d = 0.37), maintained at 3-month follow-up (d = 0.38), and 12-month follow-up (d = 0.23). No significant differences between the groups receiving DCS or placebo were found. Insomnia did not affect OCD-treatment outcome.

Discussion

This study showed that OCD treatment is associated with some improvement in insomnia symptoms. Comorbid insomnia and DCS did not moderate treatment outcome. Patients with OCD and comorbid insomnia should be considered for specific insomnia treatment.

查看原文本刊更多论文

集中暴露和反应预防对失眠症状的影响

背景强迫症（OCD）患者普遍存在失眠症状。本研究对之前的一项随机对照试验进行了二次分析，测试 d-环丝氨酸（DCS）是否能增强卑尔根 4 天疗法（B4DT）治疗强迫症的效果。在这项研究中，我们探讨了 B4DT 对难以治疗的强迫症样本中睡眠困难的影响。结果结果显示，对失眠症状的治疗效果虽小，但却很稳健（d = 0.37），并在 3 个月的随访（d = 0.38）和 12 个月的随访（d = 0.23）中保持不变。接受 DCS 或安慰剂治疗的两组之间没有发现明显差异。失眠并不影响强迫症的治疗效果。合并失眠和 DCS 并不影响治疗效果。患有强迫症并合并失眠的患者应考虑接受特定的失眠治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Obsessive-Compulsive and Related Disorders PSYCHIATRY-

CiteScore

4.00

自引率

5.60%

发文量

审稿时长

47 days

期刊介绍： Journal of Obsessive-Compulsive and Related Disorders (JOCRD) is an international journal that publishes high quality research and clinically-oriented articles dealing with all aspects of obsessive-compulsive disorder (OCD) and related conditions (OC spectrum disorders; e.g., trichotillomania, hoarding, body dysmorphic disorder). The journal invites studies of clinical and non-clinical (i.e., student) samples of all age groups from the fields of psychiatry, psychology, neuroscience, and other medical and health sciences. The journal''s broad focus encompasses classification, assessment, psychological and psychiatric treatment, prevention, psychopathology, neurobiology and genetics. Clinical reports (descriptions of innovative treatment methods) and book reviews on all aspects of OCD-related disorders will be considered, as will theoretical and review articles that make valuable contributions. Suitable topics for manuscripts include: -The boundaries of OCD and relationships with OC spectrum disorders -Validation of assessments of obsessive-compulsive and related phenomena -OCD symptoms in diverse social and cultural contexts -Studies of neurobiological and genetic factors in OCD and related conditions -Experimental and descriptive psychopathology and epidemiological studies -Studies on relationships among cognitive and behavioral variables in OCD and related disorders -Interpersonal aspects of OCD and related disorders -Evaluation of psychological and psychiatric treatment and prevention programs, and predictors of outcome.