Pregnancy and Acromegaly: About 2 Cases

Abstract

Introduction: Pregnancies in women with acromegaly are rare. Literature reports indicate the absence of fetal malformations, rarely symptomatic increases in adenoma volume, and a possible risk of gestational diabetes and pregnancy-induced hypertension in women not adequately controlled by medication before pregnancy. Variations in somatotrope function have been rarely studied. Observations: Our two patients had previously undergone surgery for somatotrope adenomas and were treated with somatostatin analogs before pregnancy, with treatment discontinued upon pregnancy diagnosis. All pregnancies were normal without gestational diabetes, pregnancy-induced hypertension, or pituitary tumor syndrome. No newborns had congenital malformations. Conclusion: Pregnancy does not appear to worsen acromegaly in young patients well-controlled with somatostatin analogs before pregnancy.