{"title":"ICP miniseries: Microbial metabolites as a way to provide crosstalk between gut and liver","authors":"M. Dekker Nitert, C. Ovadia","doi":"10.1177/1753495x241258383","DOIUrl":null,"url":null,"abstract":"Bile acid metabolism is partially regulated through the activity of the gut microbiota. Primary bile acids can be deconjugated and modified by bacteria expressing bile salt hydrolase and other enzymes, changing bile acid recycling by changing the interactions between enterocytes and hepatocytes. The modified bile acids can also activate signalling in cells regulating metabolism including colonic L-cells, skeletal muscle cells and brown adipocytes. In pregnancy, both bile acid metabolism and gut microbiota composition are altered. In women with intrahepatic cholestasis of pregnancy, the changes in bile acid metabolism are exacerbated and there is some evidence that the gut microbiota composition is also altered. Here we review the crosstalk between the liver and the gut especially in women with intrahepatic cholestasis of pregnancy, with a focus on the role of the gut microbiota in this crosstalk.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obstetric Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1753495x241258383","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Bile acid metabolism is partially regulated through the activity of the gut microbiota. Primary bile acids can be deconjugated and modified by bacteria expressing bile salt hydrolase and other enzymes, changing bile acid recycling by changing the interactions between enterocytes and hepatocytes. The modified bile acids can also activate signalling in cells regulating metabolism including colonic L-cells, skeletal muscle cells and brown adipocytes. In pregnancy, both bile acid metabolism and gut microbiota composition are altered. In women with intrahepatic cholestasis of pregnancy, the changes in bile acid metabolism are exacerbated and there is some evidence that the gut microbiota composition is also altered. Here we review the crosstalk between the liver and the gut especially in women with intrahepatic cholestasis of pregnancy, with a focus on the role of the gut microbiota in this crosstalk.
胆汁酸代谢部分受肠道微生物群活动的调节。表达胆盐水解酶和其他酶的细菌可以对初级胆汁酸进行解聚和修饰,通过改变肠细胞和肝细胞之间的相互作用来改变胆汁酸的循环。改性胆汁酸还能激活调节新陈代谢的细胞信号,包括结肠 L 细胞、骨骼肌细胞和棕色脂肪细胞。在怀孕期间,胆汁酸代谢和肠道微生物群的组成都会发生改变。在患有妊娠肝内胆汁淤积症的妇女中,胆汁酸代谢的变化会加剧,有证据表明肠道微生物群的组成也会发生改变。在此,我们回顾了肝脏和肠道之间的相互影响,尤其是妊娠肝内胆汁淤积症妇女的肝脏和肠道之间的相互影响,重点是肠道微生物群在这种相互影响中的作用。