Electrospray-Mangiferin Nanoparticles Gel: A Promising Agent for Sun and Age Defense

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-06-05 DOI:10.3390/cosmetics11030093

Neungreuthai Chomchoei, P. Leelapornpisid, P. Tipduangta, J. Sirithunyalug, B. Sirithunyalug, Pawitrabhorn Samutrtai

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引用次数: 0

Abstract

UV irradiation causes skin damage and aging. This study aimed to develop and evaluate a gel formulation loaded with electrospray mangiferin nanoparticles (MNPs) as a double-action product with photoprotective and anti-aging properties. The MNPs were prepared using the electrospraying technique and loaded in a gel formulation. The MNP formulation was evaluated regarding its physical appearance, viscosity, in vitro sun protection factor (SPF), and in vitro anti-oxidant activity and compared with a formulation containing purified mangiferin (PM) at the same concentration of 0.2% (w/v). Moreover, both formulations were analyzed for their in vitro release and ex vivo skin permeation. The MNP formulation had a considerably higher SPF value than the PM formulation at the same concentration (20.43 ± 0.13 and 12.19 ± 0.27, respectively). The in vitro anti-oxidant activities of the formulations with MNPs and PM were 74.47 ± 2.19% and 80.52 ± 1.05%, respectively. The MNP formulation showed potent photoprotective and anti-oxidation activities with acceptable stability in all parameters under accelerated conditions (4 ± 2 °C 48 h/45 ± 2 °C 48 h for 6 cycles) and after 30 days of storage under various conditions. The release profile data of the MNPs showed a controlled release pattern at 76.97 ± 0.06% at 480 min. Furthermore, after using a Franz diffusion cell for 8 h, the MNP formulation showed the release of 37.01 ± 2.61% and 22.39 ± 1.59% of mangiferin content in the skin layer as stratum corneum and viable epidermis, respectively. Therefore, the overall results demonstrate that electrospray MNPs in a gel formulation are suitable for skin and constitute a promising delivery system for mangiferin in developing cosmetics and cosmeceutical products with good potential.

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电喷雾-鱼藤素纳米颗粒凝胶：防晒抗衰老的理想制剂

紫外线照射会导致皮肤损伤和老化。本研究旨在开发和评估一种含有电喷芒果苷纳米粒子（MNPs）的凝胶配方，作为一种具有光保护和抗衰老特性的双效产品。该研究采用电喷雾技术制备了 MNPs，并将其添加到凝胶配方中。对 MNP 配方的物理外观、粘度、体外防晒系数（SPF）和体外抗氧化活性进行了评估，并与含有纯化芒果苷（PM）的相同浓度 0.2%（w/v）配方进行了比较。此外，还对两种配方的体外释放和体内皮肤渗透性进行了分析。在相同浓度下，MNP 配方的 SPF 值明显高于 PM 配方（分别为 20.43 ± 0.13 和 12.19 ± 0.27）。MNP 和 PM 制剂的体外抗氧化活性分别为 74.47 ± 2.19% 和 80.52 ± 1.05%。在加速条件下（4 ± 2 °C 48 h/45 ± 2 °C 48 h，6 个循环）以及在各种条件下储存 30 天后，MNP 制剂显示出了强大的光保护和抗氧化活性，并且在所有参数上都具有可接受的稳定性。MNPs 的释放曲线数据显示，480 分钟时的释放率为 76.97 ± 0.06%，释放模式受到控制。此外，在使用弗兰兹扩散池 8 小时后，MNP 制剂在皮肤角质层和活表皮层分别释放了 37.01 ± 2.61% 和 22.39 ± 1.59% 的芒果苷含量。因此，总体结果表明，凝胶配方中的电喷雾 MNPs 适用于皮肤，是芒果苷的一种有前途的递送系统，可用于开发具有良好潜力的化妆品和药妆产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico