Resealed Erythrocytes: A Comprehensive Review

Abstract

Among the many carriers that are turned down for administering medications to various body nerves, cellular carriers must meet a number of requirements for clinical use, the most crucial of which is the carrier's biocompatibility with its degradation products. Leucocytes, platelets, erythrocytes, Nano erythrocytes, hepatocytes, and fibroblasts etc. have been proposed as cellular carrier structures. Among these, the erythrocytes have been the most explored and have found to own better potential in drug delivery. Bio-pharmaceuticals, intensely significant peptides and proteins, antigens, anticancer drug as well as vaccines, are among the freshly attentive pharmaceuticals for being transported using carrier erythrocytes. Vaccines, antigens, and anticancer drugs are among the pharmaceuticals that have recently been targeted for delivery via carrier erythrocytes. Red blood cells, or erythrocytes, have been studied in great detail because of their possible use as drug delivery vehicles. They are special and helpful carriers because of their biocompatibility, nonpathogenicity, nonimmunogenicity, and biodegradability. To prepare carrier erythrocytes, draw blood from the target organism and separate the erythrocytes from the plasma. Through a variety of techniques, the drug is entrapped within the broken cells, resulting in the erythrocytes being resealed and referred to as "resealed erythrocytes"—the carriers of the result. Many medications, such as aspirin, steroids, Resealed erythrocytes reduce the side effects of cancer drugs, which are numerous. The current review focuses on the isolation, drug loading techniques, evaluation techniques, and drug delivery applications of sealed erythrocytes.