Evaluation of the Anticarcinogenic and Cytotoxicity Effects of Small Gold Nanorods Against Gliomablast Cell Lines in an In vitro Model

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-06 DOI:10.2174/0115734110304016240530075916

S. Özer, K. Kelleci, S. Canim-Ates, C. Canbek

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Abstract

The study aimed to evaluate the cytotoxicity and anticancer potential of gold nanorods (GNRs) synthesized using hexadecyltrimethylammonium bromide capped seed (CTAB) on L929 fibroblast cells and glioma cells. Gold nanorods were synthesized through the CTAB method, and their characterization was conducted using UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and scanning electron microscopy (SEM). The MTT cell viability assay was employed to assess the cytotoxic and anticancer effects of the synthesized gold nanorods on L929 fibroblast cells and glioma cells. Analysis results revealed that the synthesized gold nanorods had an average size of 6.4 nm and rod-like morphology, with an absorbance peak of 836 nm. The quantity of synthesized GNRs was calculated to be 3.63 μM. Cytotoxicity analysis showed an IC50 value of 1.29 μM for L929 fibroblast cells and 1.26 μM for C6 glioma cells, indicating significant cytotoxic effects. Treatment with GNRs induced apoptosis in glioma cells and inhibited their proliferation, suggesting potential anticancer activity. The findings suggest that GNRs hold promise as effective agents for cancer therapy. Further research is warranted to elucidate the precise mechanisms underlying their anticancer effects and to explore their potential clinical applications in cancer treatment.

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在体外模型中评估小金纳米棒对胶质瘤细胞株的抗癌和细胞毒性作用

该研究旨在评估用十六烷基三甲基溴化铵封端种子（CTAB）合成的金纳米棒（GNRs）对L929成纤维细胞和胶质瘤细胞的细胞毒性和抗癌潜力。研究人员用CTAB法合成了金纳米棒，并用紫外可见光谱法、傅立叶变换红外光谱法和扫描电子显微镜法对其进行了表征。分析结果表明，合成的金纳米棒平均尺寸为 6.4 nm，形态为棒状，吸光度峰值为 836 nm。经计算，合成的金纳米棒的数量为 3.63 μM。细胞毒性分析表明，对 L929 成纤维细胞的 IC50 值为 1.29 μM，对 C6 胶质瘤细胞的 IC50 值为 1.26 μM，这表明其具有显著的细胞毒性作用。研究结果表明，GNRs 有望成为治疗癌症的有效药物，需要进一步研究以阐明其抗癌作用的确切机制，并探索其在癌症治疗中的潜在临床应用。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.