Asymmetric allylic C(sp3)–C(sp3) bond functionalization

Abstract

Methods for the asymmetric functionalization of unstrained C(sp3)–C(sp3) bonds are rare. Now, strategies are developed for the enantioselective functionalization of allylic C(sp3)–C(sp3) bonds with a palladium catalyst through either kinetic resolution or dynamic kinetic asymmetric transformation.