Multi-functional Acyl Urea Compounds: A Review on Related Patents, Clinical Trials, and Synthetic Approaches

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-11 DOI:10.2174/0113852728307286240517054021

Janvi Rohilla, Rakhi Mishra, Shruti Varshney, Avijit Mazumder, Rupa Mazumder, Arvind Kumar, Amrinder Kaur

{"title":"Multi-functional Acyl Urea Compounds: A Review on Related Patents, Clinical Trials, and Synthetic Approaches","authors":"Janvi Rohilla, Rakhi Mishra, Shruti Varshney, Avijit Mazumder, Rupa Mazumder, Arvind Kumar, Amrinder Kaur","doi":"10.2174/0113852728307286240517054021","DOIUrl":null,"url":null,"abstract":"\n\nAcyl ureas are a well-known class of organic compounds that have drawn a lot of attention recently\nbecause of their array of chemical properties and possible multi-use in medicine. The article summarizes the\nsynthetic procedures used to produce various Acyl urea synthons and includes instances of clinical trials, patents,\nand commercialized medications having Acyl urea and N-acyl urea moiety. This extensive study examines\nand summarizes research on acyl urea derivatives conducted over the last 20 years from a variety of sources,\nincluding PubMed, Google Scholar, and Google Websites. When it comes to the discovery of new chemicals,\nurea derivatives still require attention compared to other acyl compounds. This review paper aims to provide a\ncomprehensive overview of the various synthetic approaches utilized in the design of an array of acyl ureas to\naccomplish the same goal. This work summarizes information related to several heteroatom-fused acyl urea\ncompounds, which fortunately will be a very useful resource for chemists and scientists who are interested in\nacyl urea synthesis and its applications in chemistry.\n","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"3 6","pages":""},"PeriodicalIF":16.4000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0113852728307286240517054021","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Acyl ureas are a well-known class of organic compounds that have drawn a lot of attention recently because of their array of chemical properties and possible multi-use in medicine. The article summarizes the synthetic procedures used to produce various Acyl urea synthons and includes instances of clinical trials, patents, and commercialized medications having Acyl urea and N-acyl urea moiety. This extensive study examines and summarizes research on acyl urea derivatives conducted over the last 20 years from a variety of sources, including PubMed, Google Scholar, and Google Websites. When it comes to the discovery of new chemicals, urea derivatives still require attention compared to other acyl compounds. This review paper aims to provide a comprehensive overview of the various synthetic approaches utilized in the design of an array of acyl ureas to accomplish the same goal. This work summarizes information related to several heteroatom-fused acyl urea compounds, which fortunately will be a very useful resource for chemists and scientists who are interested in acyl urea synthesis and its applications in chemistry.

查看原文本刊更多论文

多功能酰基脲化合物：相关专利、临床试验和合成方法综述

酰基脲是一类众所周知的有机化合物，由于其一系列的化学特性和在医药中可能的多种用途，最近引起了广泛关注。文章总结了用于生产各种酰基脲合成物的合成过程，并列举了具有酰基脲和 N-酰基脲分子的临床试验、专利和商业化药物的实例。这项内容广泛的研究从 PubMed、谷歌学术（Google Scholar）和谷歌网站（Google Websites）等各种来源审查并总结了过去 20 年中有关酰基脲衍生物的研究。与其他酰基化合物相比，在发现新化学物质方面，脲衍生物仍然需要关注。本综述论文旨在全面概述为实现同一目标而设计一系列酰基脲时所采用的各种合成方法。这项工作总结了几种杂原子融合酰基脲化合物的相关信息，对于那些对酰基脲合成及其在化学中的应用感兴趣的化学家和科学家来说，这将是一个非常有用的资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.