Understanding the Association Between Type 2 Diabetes Mellitus and Cognitive Impairment: A Single-centre Experience

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-11 DOI:10.1177/09727531241252327

T. Suvvari, Chandra Shekar Kali

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Abstract

The global prevalence of diabetes mellitus has been increasing, leading to a rise in morbidity associated with the disease. While diabetic nephropathy, retinopathy and neuropathy are routinely screened in diabetic patients, the cognitive decline associated with diabetes is often overlooked. The purpose of this study is to investigate the prevalence of cognitive impairment and its associated risk factors among patients with type 2 diabetes mellitus (T2DM). An observational cross-sectional study was conducted for two months. The Montreal Cognitive Assessment (MoCA) test, which consists of 30 questions, was used to assess cognitive function. In-depth clinical history along with glycaemic parameters were collected. The chi-square test was used to find out the association between categorical variables and cognitive impairment. Pearson’s correlation test was performed to determine the correlation between glycaemic parameters and cognitive impairment. A total of 96 patients participated in the study. The mean HbA1c (%) was 9.08 ± 1.73, and the mean MoCA score was 25.14 ± 1.63. Mild cognitive impairment (MCI) was noted in 56% patients. Attention was the most common cognitive domain defect found in all MCI patients—100%. Delayed recall and memory were the second most common cognitive domain defect found—92.5%. Higher HbA1c, high FBS and higher PPBS were found to be statistically associated with MCI. A negative correlation was found between glycaemic parameters (HbA1c, FBS and PPBS levels) and MoCA scores. More than half of our study participants reported mild cognitive impairment. It highlights the need for the implementation of routine cognitive testing for diabetes patients. There is a strong negative correlation between MoCA scores and parameters of glycaemic control; higher levels of HbA1c, FBS, and PPBS are seen in people with a lower MoCA score, indicating mild cognitive impairment. Further studies are needed to evaluate whether improving glucose levels helps in improving cognition or not.

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了解 2 型糖尿病与认知障碍之间的关系：单中心经验

全球糖尿病发病率不断上升，导致与该疾病相关的发病率上升。虽然糖尿病肾病、视网膜病变和神经病变是糖尿病患者的常规筛查项目，但与糖尿病相关的认知能力下降却常常被忽视。本研究旨在调查 2 型糖尿病（T2DM）患者中认知功能障碍的患病率及其相关风险因素。这项观察性横断面研究为期两个月。蒙特利尔认知评估（MoCA）测试包括 30 个问题，用于评估认知功能。研究人员还收集了深入的临床病史和血糖参数。采用卡方检验找出分类变量与认知障碍之间的关联。为确定血糖参数与认知障碍之间的相关性，采用了皮尔逊相关性检验。共有 96 名患者参与了研究。平均 HbA1c (%) 为 9.08 ± 1.73，平均 MoCA 得分为 25.14 ± 1.63。56%的患者存在轻度认知障碍（MCI）。在所有 MCI 患者中，注意力是最常见的认知领域缺陷，占 100%。延迟回忆和记忆是第二常见的认知缺陷，占 92.5%。高 HbA1c、高 FBS 和高 PPBS 与 MCI 有统计学关联。研究发现，血糖参数（HbA1c、FBS 和 PPBS 水平）与 MoCA 评分呈负相关。在我们的研究参与者中，半数以上报告患有轻度认知障碍。这凸显了对糖尿病患者进行常规认知测试的必要性。MoCA评分与血糖控制参数之间存在很强的负相关；MoCA评分较低的人HbA1c、FBS和PPBS水平较高，表明存在轻度认知障碍。还需要进一步的研究来评估改善血糖水平是否有助于改善认知能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.