{"title":"Unravelling the Microbiome's Role in Healing Diabetic Wounds","authors":"Sanchit Dhankhar, Nitika Garg, Samrat Chauhan, Monika Saini, Thakur Gurjeet Singh, Randhir Singh","doi":"10.2174/0113892010307032240530071003","DOIUrl":null,"url":null,"abstract":"\n\nThe process of wound healing is intricate and requires close coordination; any disruption\nto this process can have catastrophic results. It is hypothesized that chronic wounds that do\nnot heal or that cease healing entirely can be caused by a combination of host factors and bacteria\nthat are present in a wound bed or wound bed environment. There is currently a lack of understanding\nregarding the role that the cutaneous microbiome plays in the healing process of\nwounds, despite the fact that methods that do not rely on culture have revealed the role that the\ngut microbiome plays in human health and illness. In order to keep the host immune system in\ncheck, protect the epithelial barrier function, and ward off harmful microbes, skin commensals\nplay a crucial role. This review compiles the research on the effects of microbiome modifications\non wound healing and tissue regeneration from both clinical and pre-clinical investigations on a\nvariety of chronic skin wounds. It is now clear that human skin commensals, symbionts, and\npathogens all play a part in the inflammatory response, which in turn suggests a number of ways\nto treat wounds that are infected and not healing. To fully understand the function of the human\nskin microbiome in both short-term and long-term wound healing, additional study is required to\nreconcile the conflicting and contentious results of previous investigations.\n","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current pharmaceutical biotechnology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0113892010307032240530071003","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The process of wound healing is intricate and requires close coordination; any disruption
to this process can have catastrophic results. It is hypothesized that chronic wounds that do
not heal or that cease healing entirely can be caused by a combination of host factors and bacteria
that are present in a wound bed or wound bed environment. There is currently a lack of understanding
regarding the role that the cutaneous microbiome plays in the healing process of
wounds, despite the fact that methods that do not rely on culture have revealed the role that the
gut microbiome plays in human health and illness. In order to keep the host immune system in
check, protect the epithelial barrier function, and ward off harmful microbes, skin commensals
play a crucial role. This review compiles the research on the effects of microbiome modifications
on wound healing and tissue regeneration from both clinical and pre-clinical investigations on a
variety of chronic skin wounds. It is now clear that human skin commensals, symbionts, and
pathogens all play a part in the inflammatory response, which in turn suggests a number of ways
to treat wounds that are infected and not healing. To fully understand the function of the human
skin microbiome in both short-term and long-term wound healing, additional study is required to
reconcile the conflicting and contentious results of previous investigations.
期刊介绍:
Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:
DNA/protein engineering and processing
Synthetic biotechnology
Omics (genomics, proteomics, metabolomics and systems biology)
Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
Drug delivery and targeting
Nanobiotechnology
Molecular pharmaceutics and molecular pharmacology
Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
Pharmacokinetics and pharmacodynamics
Applied Microbiology
Bioinformatics (computational biopharmaceutics and modeling)
Environmental biotechnology
Regenerative medicine (stem cells, tissue engineering and biomaterials)
Translational immunology (cell therapies, antibody engineering, xenotransplantation)
Industrial bioprocesses for drug production and development
Biosafety
Biotech ethics
Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.
Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.