A specific olfactory bulb interneuron subtype Tpbg/5T4 generated at embryonic and neonatal stages

IF 3.4 3区医学 Q2 NEUROSCIENCES

Frontiers in Neural Circuits Pub Date : 2024-06-12 DOI:10.3389/fncir.2024.1427378

Akio Tsuboi

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Abstract

Various mammals have shown that sensory stimulation plays a crucial role in regulating the development of diverse structures, such as the olfactory bulb (OB), cerebral cortex, hippocampus, and retina. In the OB, the dendritic development of excitatory projection neurons like mitral/tufted cells is influenced by olfactory experiences. Odor stimulation is also essential for the dendritic development of inhibitory OB interneurons, such as granule and periglomerular cells, which are continuously produced in the ventricular-subventricular zone throughout life. Based on the morphological and molecular features, OB interneurons are classified into several subtypes. The role for each interneuron subtype in the control of olfactory behavior remains poorly understood due to lack of each specific marker. Among the several OB interneuron subtypes, a specific granule cell subtype, which expresses the oncofetal trophoblast glycoprotein (Tpbg or 5T4) gene, has been reported to be required for odor detection and discrimination behavior. This review will primarily focus on elucidating the contribution of different granule cell subtypes, including the Tpbg/5T4 subtype, to olfactory processing and behavior during the embryonic and adult stages.

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在胚胎和新生儿阶段产生的特异性嗅球中间神经元亚型 Tpbg/5T4

各种哺乳动物的研究表明，感官刺激在调节嗅球（OB）、大脑皮层、海马和视网膜等不同结构的发育中发挥着至关重要的作用。在嗅球中，兴奋性投射神经元（如二尖瓣/簇细胞）树突的发育受到嗅觉经验的影响。气味刺激对抑制性 OB 中间神经元（如颗粒细胞和周围细胞）的树突发育也至关重要，这些神经元在脑室-室下区终生不断产生。根据形态和分子特征，OB 中间神经元可分为几个亚型。由于缺乏各种特异性标记，人们对每种中间神经元亚型在控制嗅觉行为中的作用仍然知之甚少。据报道，在几种嗅觉中间神经元亚型中，一种表达胎盘滋养层糖蛋白（Tpbg 或 5T4）基因的特定颗粒细胞亚型是气味检测和辨别行为所必需的。本综述将主要侧重于阐明不同颗粒细胞亚型（包括 Tpbg/5T4 亚型）对胚胎期和成年期嗅觉处理和行为的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neural Circuits NEUROSCIENCES-

CiteScore

6.00

自引率

5.70%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Frontiers in Neural Circuits publishes rigorously peer-reviewed research on the emergent properties of neural circuits - the elementary modules of the brain. Specialty Chief Editors Takao K. Hensch and Edward Ruthazer at Harvard University and McGill University respectively, are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics and the public worldwide. Frontiers in Neural Circuits launched in 2011 with great success and remains a "central watering hole" for research in neural circuits, serving the community worldwide to share data, ideas and inspiration. Articles revealing the anatomy, physiology, development or function of any neural circuitry in any species (from sponges to humans) are welcome. Our common thread seeks the computational strategies used by different circuits to link their structure with function (perceptual, motor, or internal), the general rules by which they operate, and how their particular designs lead to the emergence of complex properties and behaviors. Submissions focused on synaptic, cellular and connectivity principles in neural microcircuits using multidisciplinary approaches, especially newer molecular, developmental and genetic tools, are encouraged. Studies with an evolutionary perspective to better understand how circuit design and capabilities evolved to produce progressively more complex properties and behaviors are especially welcome. The journal is further interested in research revealing how plasticity shapes the structural and functional architecture of neural circuits.