Paeoniae Radix Alba and Network Pharmacology Approach for Osteoarthritis: A Review

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-06-12 DOI:10.3390/separations11060184

Bo Wang, Changcai Bai, Yuanyuan Zhang

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引用次数: 0

Abstract

Osteoarthritis (OA) is the most common type of arthritis and affects more than 240 million people worldwide; the most frequently affected areas are the hips, knees, feet, and hands. OA pathophysiology is multifactorial, involving genetic, developmental, metabolic, traumatic, and inflammation factors. Therefore, treatments able to address several path mechanisms can help control OA. Network pharmacology is developing as a next-generation research strategy to shift the paradigm of drug discovery from “one drug, one target” to “multi-component, multi-target”. In this paper, network pharmacology is employed to investigate the potential role of Paeoniae Radix Alba (PRA) in the treatment of OA. PRA is a natural product known for its protective effects against OA, which has recently drawn attention because of its ability to provide physiological benefits with fewer toxic effects. This review highlights the anti-inflammatory properties of PRA in treating OA. PRA can be used alone or in combination with conventional therapies to enhance their effectiveness and reduce side effects. The study also demonstrates the use of network pharmacology as a cost-effective and time-saving method for predicting therapeutic targets of PRA in OA treatment.

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治疗骨关节炎的白芍和网络药理学方法：综述

骨关节炎（OA）是最常见的关节炎类型，影响着全球超过 2.4 亿人；最常受影响的部位是髋、膝、足和手。OA 的病理生理学是多因素的，涉及遗传、发育、代谢、创伤和炎症等因素。因此，针对多种病理机制的治疗方法有助于控制 OA。网络药理学正在发展成为下一代研究策略，将药物发现的范式从 "一药一靶 "转变为 "多成分、多靶点"。本文采用网络药理学研究白芍（PRA）在治疗 OA 中的潜在作用。PRA 是一种天然产品，以其对 OA 的保护作用而闻名，最近因其能在提供生理益处的同时减少毒副作用而备受关注。本综述重点介绍 PRA 在治疗 OA 方面的抗炎特性。PRA 可单独使用，也可与传统疗法结合使用，以提高疗效并减少副作用。该研究还证明了网络药理学是预测 PRA 在治疗 OA 中的治疗靶点的一种既经济又省时的方法。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.