Hapten-Mediated Chemical Immune Therapy with Drug Administration into Cervical Cancer without Hysterectomy:Awakening Immune Cells for Immunotherapy

Abstract

Background: Cervical cancer is one of the most common and deadly cancers in women, for whom with persistent infection of High-Risk Human Papillomavirus (HPV). Current treatment of cervical cancer involves radical hysterectomy, radiotherapy and chemotherapy or a combination. Objective: We to define if Hapten Enhanced Intratumoral Chemotherapy (HEIC) was effective in boosting immunity for effective treatment of cervical cancer lesions. Study Design: We used Single-Cell RNA Sequencing (scRNA-Seq) to obtain transcriptome profiles of 40239 cells from biopsies of cervical cancer lesions at the cervix directly from one patient before the start of HEIC and about 1 week after HEIC. The blood