3D printing and development of computational models of biodegradable meshes for pelvic organ prolapse

IF 1.5 4区 工程技术 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
Maria Francisca Reis Rabaça Vaz, M. E. Silva, M. Parente, Sofia Brandão, A. A. Fernandes
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Abstract

PurposeDevelop biodegradable meshes as a novel solution to address issues associated with using synthetic meshes for POP repair.Design/methodology/approachComputational models were created with variations in the pore geometry, pore size, filament thickness, and inclusion of filaments around specific mesh regions. Subsequently, one of the meshes was 3D printed to validate the results obtained from the simulations. Following this, a uniaxial tensile test was carried out on the vaginal tissue of a sow to compare with the simulations, to identify meshes that displayed behaviour akin to vaginal tissue. Finally, the most promising outcomes were compared with those of the uterosacral ligament and a commercially available mesh.FindingsFollowing a comprehensive analysis of the results, the mesh that most accurately replicates the behaviour of the vaginal tissue showcases a smaller pore diameter (1.50 mm), filaments in specific areas of the mesh, and variable filament thickness across the mesh. Nevertheless, upon comparing the outcomes with those of the uterosacral, the meshes do not exhibit similar behaviour to the ligament. Finally, the commercially available mesh does not represent the behaviour of both the vaginal tissue and the uterosacral ligament and in this sense may not be the best treatment option for POP repair.Originality/valueTheir biocompatibility and biomechanical properties make them a potential solution to the disadvantages of synthetic meshes. Personalized/customized meshes could be part of the future of surgical POP repair.
三维打印和盆腔器官脱垂生物可降解网格计算模型的开发
目的开发生物可降解网格,作为一种新型解决方案,解决与使用合成网格进行持久性有机污染物修复相关的问题。随后,对其中一个网格进行 3D 打印,以验证模拟结果。随后,对母猪的阴道组织进行了单轴拉伸试验,与模拟结果进行比较,以确定哪些网格的行为类似于阴道组织。最后,将最有希望的结果与子宫骶骨韧带和市场上销售的网片进行了比较。研究结果在对结果进行综合分析后,最准确地复制阴道组织行为的网片显示出较小的孔径(1.50 毫米)、网片特定区域的丝状物以及整个网片的不同丝状物厚度。然而,将结果与子宫骶骨的结果进行比较后发现,这些网片并没有表现出与韧带类似的行为。最后,市售的网片并不能代表阴道组织和子宫骶骨韧带的特性,从这个意义上讲,它可能不是 POP 修复的最佳治疗方案。个性化/定制网片可能成为未来 POP 手术修复的一部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Engineering Computations
Engineering Computations 工程技术-工程:综合
CiteScore
3.40
自引率
6.20%
发文量
61
审稿时长
5 months
期刊介绍: The journal presents its readers with broad coverage across all branches of engineering and science of the latest development and application of new solution algorithms, innovative numerical methods and/or solution techniques directed at the utilization of computational methods in engineering analysis, engineering design and practice. For more information visit: http://www.emeraldgrouppublishing.com/ec.htm
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