Social transmission of inflammation

IF 5.9 3区 农林科学 Q1 VETERINARY SCIENCES
Jorge Ferreira
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引用次数: 0
炎症的社会传播
在许多物种中,群体成员会对同类的生理和情绪状态做出反应。在某些情况下,会出现情感镜像,即情感状态似乎会从一个同类传递给另一个同类。然而,目前还不清楚在炎症状态下是否会出现同样的现象。在最近的一份预印本(未经同行评审)中,Quintana 等人探索了炎症在小鼠中的潜在传播。在给小鼠幼崽注射脂多糖(LPS)诱发炎症后,研究人员发现小鼠母亲体内的皮质酮水平上升,母性行为也有所增加。定量 PCR 还显示,母鼠大脑中的炎症转录物有所增加。当把注射了 LPS 的幼鼠放在母鼠隔壁的笼子里时,母鼠仍然会表现出这种炎症状态,这表明炎症的社会传播可能并不需要身体接触。一对一起饲养的成年雌性动物在其中一只雌性动物被注射了 LPS 后,炎症的社会传播并没有出现,这表明炎症的社会传播在不同年龄段和不同关系的动物中效果并不一致。然而,旁观的雌性动物对LPS的反应更强烈,这表明接触成年患病动物会增强对LPS的炎症反应。这些发现强调了炎症的社会传播,补充了之前关于恐惧和疼痛的社会传播的研究:Quintana, S.C. et al. Preprint at bioRxiv https://doi.org/10.1101/2024.02.29.582723 (2024)
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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