Increased thyroid stimulating hormone (TSH) as a possible risk factor for atherosclerosis in subclinical hypothyroidism.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Basil Mohammed Alomair, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Majed Ayed Alshammari, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batiha
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引用次数: 0

Abstract

Primary hypothyroidism (PHT) is associated with an increased risk for the development of atherosclerosis (AS) and other cardiovascular disorders. PHT induces atherosclerosis (AS) through the induction of endothelial dysfunction, and insulin resistance (IR). PHT promotes vasoconstriction and the development of hypertension. However, patients with subclinical PHT with normal thyroid hormones (THs) are also at risk for cardiovascular complications. In subclinical PHT, increasing thyroid stimulating hormone (TSH) levels could be one of the causative factors intricate in the progression of cardiovascular complications including AS. Nevertheless, the mechanistic role of PHT in AS has not been fully clarified in relation to increased TSH. Therefore, in this review, we discuss the association between increased TSH and AS, and how increased TSH may be involved in the pathogenesis of AS. In addition, we also discuss how L-thyroxine treatment affects the development of AS.

促甲状腺激素(TSH)升高可能是亚临床甲状腺功能减退症导致动脉粥样硬化的危险因素。
原发性甲状腺功能减退症(PHT)与动脉粥样硬化(AS)和其他心血管疾病的发病风险增加有关。PHT通过诱导内皮功能障碍和胰岛素抵抗(IR)诱发动脉粥样硬化(AS)。PHT 会促进血管收缩并引发高血压。然而,甲状腺激素(THs)正常的亚临床 PHT 患者也有发生心血管并发症的风险。在亚临床 PHT 患者中,促甲状腺激素(TSH)水平的升高可能是导致包括强直性脊柱炎在内的心血管并发症进展的复杂致病因素之一。然而,PHT在强直性脊柱炎中与促甲状腺激素升高有关的机理作用尚未完全阐明。因此,在这篇综述中,我们讨论了促甲状腺激素增高与强直性脊柱炎之间的关联,以及促甲状腺激素增高可能如何参与强直性脊柱炎的发病机制。此外,我们还讨论了左旋甲状腺素治疗如何影响强直性脊柱炎的发病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Thyroid Research
Thyroid Research Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
3.10
自引率
4.50%
发文量
21
审稿时长
8 weeks
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