Osteosarcopenia: the coexistence of sarcopenia and osteopenia is predictive of prognosis and postoperative complications after curative resection for colorectal cancer.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2024-06-16 DOI:10.1007/s00595-024-02883-1

Takaaki Fujimoto, Koji Tamura, Kinuko Nagayoshi, Yusuke Mizuuchi, Yoshio Oh, Tsukasa Nara, Hiroshi Matsumoto, Kohei Horioka, Koji Shindo, Kohei Nakata, Kenoki Ohuchida, Masafumi Nakamura

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引用次数: 0

Abstract

Purpose: To establish if osteosarcopenia is related to postoperative complications, prognosis, and recurrence of colorectal cancer (CRC) after curative surgery.

Methods: The clinical data of 594 patients who underwent curative resection for CRC between January, 2013 and December, 2018 were analyzed retrospectively to examine the relationship between clinicopathological data and osteosarcopenia. The following definitions were used: sarcopenia, low skeletal muscle mass index; osteopenia, low bone mineral density on computed tomography at the level of the 11th thoracic vertebra; and osteosarcopenia, sarcopenia with osteopenia.

Results: Osteosarcopenia was identified in 98 patients (16.5%) and found to be a significant risk factor for postoperative complications (odds ratio 2.53; p = 0.011). The 5-year overall survival (OS) and recurrence-free survival (RFS) rates of the patients with osteosarcopenia were significantly lower than those of the patients without osteosarcopenia (OS: 72.5% and 93.9%, respectively, p < 0.0001; RFS: 70.8% and 92.4%, respectively, p < 0.0001). Multivariate analysis identified osteosarcopenia as an independent prognostic factor associated with OS (hazard ratio 3.31; p < 0.0001) and RFS (hazard ratio 3.67; p < 0.0001).

Conclusion: Osteosarcopenia may serve as a predictor of postoperative complications and prognosis after curative surgery for CRC.

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骨质疏松症：肌肉疏松症和骨质疏松症并存可预测结肠直肠癌根治性切除术后的预后和术后并发症。

目的：确定骨肉疏松症是否与结直肠癌（CRC）根治性手术后的术后并发症、预后和复发有关：方法：回顾性分析2013年1月至2018年12月期间接受治愈性切除术的594例CRC患者的临床数据，研究临床病理数据与骨肌少症之间的关系。采用以下定义：肌少症，骨骼肌质量指数低；骨质疏松症，第11胸椎水平计算机断层扫描骨矿密度低；骨肉疏松症，肌少症合并骨质疏松症：结果：98 名患者（16.5%）发现了骨肉疏松症，并发现它是术后并发症的重要风险因素（几率比 2.53；P = 0.011）。骨肉疏松症患者的 5 年总生存率（OS）和无复发生存率（RFS）明显低于无骨肉疏松症患者（OS：72.5%；RFS：93.9%；P 结论：骨肉疏松症可能是癌症术后并发症的重要风险因素：骨肌肉疏松症可能是预测 CRC 根治性手术后并发症和预后的一个因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.