Impact of surface chemical treatment in surgical regenerative treatment of ligature-induced peri-implantitis: A canine study

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Shu-Jiao Qian, Yi-Wen Tsai, Theofilos Koutouzis, Hong-Chang Lai, Shi-Chong Qiao, Georgios A. Kotsakis
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引用次数: 0

Abstract

Background

Implant surface decontamination is a critical step in peri-implantitis treatment. The aim of this study was to assess the effect chemotherapeutic agents have on reosseointegration after treatment on ligature-inducted peri-implantitis.

Methods

Six male canines had 36 implants placed and ligatures were placed around them for 28 weeks to establish peri-implantitis. The peri-implant defects were randomly treated by 1 of 3 methods: 0.12% chlorhexidine (CHX test group), 1.5% sodium hypochlorite (NaOCl test group), or saline (Control group). Sites treated with NaOCl and CHX were grafted with autogenous bone, and all sites then either received a collagen membrane or not. Histology sections were obtained at 6 months postsurgery to assess percentage of reosseointegration.

Results

Thirty-five implants were analyzed (CHX: 13; NaOCl: 14; Control:8). NaOCl-treated sites demonstrated reosseointegration with direct bone-to-implant-contact on the previously contaminated surfaces (42% mean reosseointegration), which was significantly higher than Controls (p < 0.05). Correspondingly, clinical improvement was noted with a significant reduction in probing depth from 5.50 ± 1.24 mm at baseline to 4.46 ± 1.70 mm at 6-months postsurgery (p = 0.006). CHX-treated sites demonstrated a nonsignificant reosseointegration of 26% (p > 0.05); however, in the majority of cases, the new bone growth was at a distance from the implant surface without contact. Probing depths did not improve in the CHX group. The use of membrane did not influence reosseointegration or probing depths (all p > 0.05).

Conclusion

Titanium implants with peri-implantitis have the capacity to reosseointegrate following regenerative surgery. However, treatment response is contingent upon the chemotherapeutic agent selection. Additional chemical treatment with 1.5% NaOCl lead to the most favorable results in terms of changes in defect depth and percentage of reosseointegration as compared to CHX, which may hinder reosseointegration.

Abstract Image

表面化学处理对结扎引起的种植体周围炎手术再生治疗的影响:犬类研究
背景:种植体表面净化是治疗种植体周围炎的关键步骤。本研究的目的是评估化疗药物对结扎引起的种植体周围炎治疗后的再骨结合的影响:方法:六颗雄性犬牙植入了36颗种植体,并在种植体周围植入结扎带28周,以建立种植体周围炎。种植体周围缺损随机采用三种方法中的一种进行治疗:0.12% 洗必泰(CHX 试验组)、1.5% 次氯酸钠(NaOCl 试验组)或生理盐水(对照组)。用 NaOCl 和 CHX 处理过的部位会移植自体骨,然后所有部位都会接受或不接受胶原蛋白膜。术后 6 个月时进行组织学切片检查,以评估再骨合的百分比:对 35 个种植体进行了分析(CHX:13 个;NaOCl:14 个;对照组:8 个)。经 NaOCl 处理过的部位显示,在先前污染的表面上,骨与种植体直接接触,实现了再骨结合(平均再骨结合率为 42%),明显高于对照组(P 0.05);但在大多数情况下,新骨生长与种植体表面有一定距离,没有接触。CHX 组的探查深度没有改善。膜的使用对再骨结合或探诊深度没有影响(均 p > 0.05):结论:患有种植体周围炎的钛种植体有能力在再生手术后重新骨结合。然而,治疗反应取决于化疗药物的选择。与可能阻碍再结合的 CHX 相比,使用 1.5% NaOCl 进行额外的化学处理在缺损深度变化和再结合百分比方面取得了最理想的效果。
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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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