Donor site wound healing following free gingival graft surgery using platelet rich fibrin: A randomized controlled trial

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Se'quon M. H. Scott, Julia A. Lacy, Archontia A. Palaiologou, Georgios A. Kotsakis, David E. Deas, Brian L. Mealey
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引用次数: 0

Abstract

Background

The primary purpose of this two-arm, parallel design, randomized controlled study is to compare healing of the palatal tissue donor site when platelet-rich fibrin (PRF) is used as a wound dressing compared to the use of a hemostatic agent. Secondary outcomes of patient pain perception and analgesic intake were also evaluated.

Methods

Seventy-four patients receiving free gingival grafts were randomized to receive either PRF (test) or hemostatic agent (control) as a palatal wound dressing by patients selecting a sealed envelope containing their group assignment (initially 37 envelopes for PRF group and 37 for hemostatic agent group). Patient pain assessment and analgesic consumption were documented using a 21-point numerical scale (NMRS-21) at 24, 48, and 72 hours post-surgery. At 1-, 2-, 3-, and 4-week follow-up appointments palatal early healing index (PEHI) scores including wound color, epithelialization, presence or absence of swelling, granulation tissue, and bleeding on gentle palpation were generated by direct intraoral examination by a blinded examiner unaware of the patients’ treatment group.

Results

NMRS-21 pain scores showed a significant reduction in pain over time in both groups, with no significant difference between groups at any time point. No significant between-group difference was found in the amount of analgesics taken by patients at 24, 48, and 72 hours. There was significant improvement in PEHI scores over the 4-week time period in both groups, but there was no significant difference in PEHI score at each time point (1, 2, 3, 4 weeks) between groups. 

Conclusions

Study findings suggest that there is no difference in early palatal wound healing, patient pain perception, or analgesic consumption between use of PRF or a hemostatic agent as donor-site wound dressings.

使用富血小板纤维蛋白进行游离龈移植手术后供体部位的伤口愈合:随机对照试验
研究背景这项双臂、平行设计、随机对照研究的主要目的是比较使用富血小板纤维蛋白(PRF)作为伤口敷料与使用止血剂时腭组织供体部位的愈合情况。研究还评估了患者疼痛感和镇痛剂摄入量的次要结果:74名接受游离牙龈移植的患者被随机分配到PRF(试验组)或止血剂(对照组)作为腭部伤口敷料。在手术后 24、48 和 72 小时,使用 21 点数字量表(NMRS-21)记录患者的疼痛评估和止痛药消耗量。在 1、2、3 和 4 周的随访中,腭部早期愈合指数(PEHI)评分包括伤口颜色、上皮化、有无肿胀、肉芽组织和轻轻触诊时的出血情况,评分由一名不知道患者治疗组别的盲人检查员通过直接口腔内检查得出:结果:NMRS-21 疼痛评分显示,两组患者的疼痛均随时间推移而明显减轻,组间在任何时间点均无明显差异。在 24、48 和 72 小时内,患者服用镇痛药的剂量在组间无明显差异。在为期四周的时间里,两组患者的 PEHI 评分均有明显改善,但在每个时间点(1、2、3、4 周),两组患者的 PEHI 评分均无明显差异。 结论:研究结果表明,使用 PRF 或止血剂作为供体部位伤口敷料,在早期腭部伤口愈合、患者疼痛感觉或镇痛药消耗方面没有差异。
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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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