The role of macrophage migration inhibitory factor family and CD74 in the pathogenesis of melanoma

IF 3.5 3区 医学 Q1 DERMATOLOGY
Keiji Tanese, Dai Ogata
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引用次数: 0

Abstract

Melanoma is an aggressive tumour with poor prognosis that arises from the malignant transformation of melanocytes. Over the past few decades, intense research into the pathogenesis of melanoma has led to the development of BRAF and immune checkpoint inhibitors, including antibodies against programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4), which have shown clinically significant efficacy. However, some tumours do not respond to these therapies initially or become treatment resistant. Most melanoma tissues appear to possess biological characteristics that allow them to evade these treatments, and identifying these characteristics is one of the major challenges facing cancer researchers. One such characteristic that has recently gained attention is the role of macrophage migration inhibitory factor (MIF) and its receptor CD74. This review outlines the cellular and molecular functions of CD74, MIF and their family of proteins. We then review their roles in tumours based on previous reports, highlight their pathological significance in melanoma and discuss their potential as therapeutic targets.

Abstract Image

巨噬细胞迁移抑制因子家族和 CD74 在黑色素瘤发病机制中的作用。
黑色素瘤是一种预后不良的侵袭性肿瘤,由黑色素细胞恶性转化而来。过去几十年来,人们对黑色素瘤的发病机制进行了深入研究,开发出了 BRAF 和免疫检查点抑制剂,包括针对程序性细胞死亡蛋白 1(PD-1)和细胞毒性 T 淋巴细胞相关蛋白 4(CTLA-4)的抗体,并取得了显著的临床疗效。然而,有些肿瘤最初对这些疗法没有反应,或者产生耐药性。大多数黑色素瘤组织似乎都具有能够逃避这些疗法的生物学特征,而确定这些特征正是癌症研究人员面临的主要挑战之一。巨噬细胞迁移抑制因子(MIF)及其受体 CD74 的作用是最近备受关注的特征之一。本综述概述了 CD74、MIF 及其蛋白家族的细胞和分子功能。然后,我们根据以往的报道回顾了它们在肿瘤中的作用,强调了它们在黑色素瘤中的病理意义,并讨论了它们作为治疗靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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