Corrigendum to: A logical model of Ewing sarcoma cell epithelial-to-mesenchymal transition supports the existence of hybrid cellular phenotypes https://doi.org/10.1002/1873-3468.14724

IF 3.5 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
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Abstract

This corrigendum has been published to correct errors identified by the authors after publication. These errors were introduced during the preparation of the figures and table. The authors sincerely apologize for any confusion that those minor errors in the original version of this article may have created and emphasize that these mistakes do not affect the conclusions of the article.

Fig. 3. Analysis of model perturbation and state transitions. (A) The stable states resulting from perturbations applied to circuit components are depicted in A. The left-most figure represents the perturbations and the right-most one denotes the stable states, similar to the format used in Fig. 2. The asterisk (*) is employed to indicate that the corresponding component within a given model state can be activated or inactivated. (B) The combined loss (down arrow) and gain (up arrow) of function of the circuit components resulted in abrogated states and subsequent loss of multistability of the wild-type case. E, H, and M represent epithelial, hybrid, and mesenchymal states, respectively. (C) State transition graphs (STGs) depict the transition from the hybrid state for EWS/FLI1 fusion OFF and TGF-β OFF, with miR-145 (upper network) and miR-200 (lower network) capable of assuming all of their possible levels (OFF or ON). (D) Transitions from hybrid states (identified by activation or inactivation of SOX2 and OCT4) for EWS/FLI1 Fusion ON under identical conditions as in (C) for miR-200 (upper network) and miR-145 (lower network). Blue nodes represent transient states, and arrows represent transitions in which the state of the components is represented by plus (+) and minus (−) signs, respectively, denoting component activation or inactivation.

Abstract Image

更正:尤文肉瘤细胞上皮向间质转化的逻辑模型支持混合细胞表型的存在 https://doi.org/10.1002/1873-3468.14724。
发表本更正是为了纠正作者在文章发表后发现的错误。这些错误是在编制图表时出现的。作者对本文原版中的这些小错误可能造成的任何混淆表示诚挚的歉意,并强调这些错误并不影响文章的结论。模型扰动和状态转换分析。(最左边的图表示扰动,最右边的图表示稳定状态,与图 2 中使用的格式类似。星号(*)表示特定模型状态下的相应元件可以激活或失活。(B) 电路元件功能的丧失(向下箭头)和增益(向上箭头)共同导致了野生型状态的消减和随后多稳态性的丧失。E、H 和 M 分别代表上皮、混合和间质状态。(C) 状态转换图(STGs)描述了 EWS/FLI1 融合关闭和 TGF-β 关闭时从混合状态的转换,miR-145(上部网络)和 miR-200(下部网络)能够假设其所有可能的水平(关闭或打开)。(D) 在与 (C) 相同的条件下,miR-200(上层网络)和 miR-145(下层网络)从 EWS/FLI1 Fusion ON 的混合状态(通过 SOX2 和 OCT4 的激活或失活确定)过渡。蓝色节点代表瞬态,箭头代表转换,其中各成分的状态分别用正号(+)和负号(-)表示,表示成分激活或失活。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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