The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis—A systematic review and meta-analysis

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research Pub Date : 2024-06-16 DOI:10.1002/cre2.907

Khadijah Mohideen, Chandrasekaran Krithika, T. Jeyanthikumari, N. V. Vani, Safal Dhungel, Snehashish Ghosh

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Abstract

Objective

The present systematic review explored the involvement of enzymatic and nonenzymatic antioxidants in periodontitis, drawing from established literature.

Materials and Methods

The research approach encompassed an extensive electronic search from 2000 to 2023 across databases such as PubMed, Science Direct, and Wiley Online Library and cross-referencing using specific keywords.

Results

The initial literature exploration generated a total of 766 articles. After thoroughly examining the abstracts, 693 articles were excluded from consideration due to duplication and lack of relevance to the central research inquiry. Following that, 73 articles were left for in-depth evaluation. Following a qualitative assessment, 35 studies that satisfied the inclusion criteria were chosen, while 38 were removed for not meeting the necessary standards. Within this selection, a meta-analysis was conducted on 11 articles that provided consistent data for quantitative synthesis. Specifically, the analysis of glutathione (GSH) levels in serum samples revealed a standardized mean difference (SMD) of −5.552 µg/mL (CI 95%: −9.078 to −2.026; P-0.002). In contrast, the analysis of glutathione peroxidase (GPx) enzymes in gingival crevicular fluid (GCF) samples displayed an overall SMD of 2.918 ng/µL (CI 95%: 0.372–5.465; P-0.025), while salivary samples exhibited an overall SMD value of 0.709 U/l (95% CI: −1.907–3.325; P-0.596) which is of insignificant.

Conclusion

The systematic review findings suggest a notable decrease in antioxidant enzymes across various systemic biological samples among patients with periodontitis, contrasting with the results from gingival tissue samples meta-analysis of GPx enzyme.

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牙周炎患者谷胱甘肽、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和氧化谷胱甘肽的评估--系统综述和荟萃分析。

目的：本系统综述从已有文献中汲取资料，探讨了酶和非酶抗氧化剂在牙周炎中的作用：研究方法包括从 2000 年到 2023 年在 PubMed、Science Direct 和 Wiley Online Library 等数据库中进行广泛的电子检索，并使用特定关键词进行交叉引用：最初的文献探索共收集到 766 篇文章。在对摘要进行深入研究后，有 693 篇文章因重复和与中心研究调查缺乏相关性而被排除在外。之后，留下 73 篇文章进行深入评估。经过定性评估，35 篇符合纳入标准的研究被选中，38 篇因不符合必要标准而被剔除。在这一选择范围内，对 11 篇为定量综合提供了一致数据的文章进行了荟萃分析。具体来说，对血清样本中谷胱甘肽（GSH）水平的分析表明，其标准化平均差（SMD）为-5.552 µg/mL (CI 95%: -9.078 to -2.026; P-0.002)。相比之下，对牙龈缝隙液（GCF）样本中谷胱甘肽过氧化物酶（GPx）的分析显示，总体 SMD 为 2.918 ng/µL（CI 95%：0.372-5.465；P-0.025），而唾液样本显示的总体 SMD 值为 0.709 U/l （95% CI：-1.907-3.325；P-0.596），微不足道：系统综述结果表明，牙周炎患者各种系统生物样本中的抗氧化酶明显减少，这与牙龈组织样本中 GPx 酶的荟萃分析结果形成了鲜明对比。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.

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