Effects of combined training on nonshivering thermogenic activity of muscles in individuals with overweight and type 2 diabetes

IF 1.3 4区 医学 Q4 PHYSIOLOGY
Enrico Antonio Rautenberg Finardi, Ivan Luiz Padilha Bonfante, Milena Monfort-Pires, Renata Garbellini Duft, Keryma Chaves da Silva Mateus, Sergio Querino Brunetto, Mara Patricia T. Chacon-Mikahil, Celso Darío Ramos, Licio Augusto Velloso, Cláudia R. Cavaglieri
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Abstract

Background

Increased thermogenic activity has shown to be a promising target for treating and preventing obesity and type 2 diabetes (T2DM). Little is known about the muscular influence on nonshivering thermogenesis (NST), and it remains unclear whether physical training and potential metabolic improvements could be associated with changes in this type of thermogenic activity.

Objective

The present study aimed to assess muscular NST activity in overweight and T2DM before and after a combined training period (strength training followed by aerobic exercise).

Methods

Nonshivering cold-induced 18-fluoroxyglucose positron emission computed tomography (18F-FDG PET/CT) was performed before and after 16 weeks of combined training in 12 individuals with overweight and T2DM. The standard uptake value (SUV) of 18F-FDG was evaluated in skeletal muscles, the heart and the aorta.

Results

Muscles in the neck region exhibit higher SUV pre- and posttraining. Furthermore, a decrease in glucose uptake by the muscles of the lower and upper extremities and in the aorta was observed after training when adjusted for brown adipose tissue (BAT). These pre–post effects are accompanied by increased cardiac SUV and occur concurrently with heightened energy expenditure and metabolic improvements.

Conclusions

Muscles in the neck region have greater metabolic activity upon exposure to cold. In addition, combined training appears to induce greater NST, favoring the trunk and neck region compared to limbs based on joint work and adaptations between skeletal muscles and BAT.

联合训练对超重和 2 型糖尿病患者肌肉非颤抖性生热活动的影响。
背景:增加生热活动已被证明是治疗和预防肥胖症和 2 型糖尿病(T2DM)的一个有前途的目标。人们对肌肉对非颤抖性产热(NST)的影响知之甚少,目前仍不清楚体育训练和潜在的代谢改善是否与这类产热活动的变化有关:本研究旨在评估超重和 T2DM 患者在联合训练期(力量训练后进行有氧运动)前后的肌肉 NST 活性:方法:在 12 名超重和 T2DM 患者进行为期 16 周的联合训练之前和之后,对他们进行了非颤抖冷诱导 18 氟氧葡萄糖正电子发射计算机断层扫描(18F-FDG PET/CT)。评估了骨骼肌、心脏和主动脉的 18F-FDG 标准摄取值(SUV):结果:训练前后,颈部肌肉的 SUV 值均较高。此外,在对棕色脂肪组织(BAT)进行调整后,还观察到训练后上下肢肌肉和主动脉对葡萄糖的吸收减少。这些前后效应伴随着心脏SUV的增加,并与能量消耗的增加和新陈代谢的改善同时发生:结论:颈部肌肉在暴露于寒冷环境时具有更强的新陈代谢活性。结论:颈部肌肉在暴露于寒冷环境时具有更强的新陈代谢活动。此外,联合训练似乎会诱发更强的 NST,与四肢相比,更有利于躯干和颈部。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.40
自引率
5.60%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.
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