Exploring the Potential of MIM-Manufactured Porous NiTi as a Vascular Drug Delivery Material

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL
Yang Zhou, Tun Wang, Peng Lu, Zicheng Wan, Hao He, Junwei Wang, Dongyang Li, Yimin Li, Chang Shu
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Abstract

Porous nickel-titanium (NiTi) manufactured using metal injection molding (MIM) has emerged as an innovative generation of drug-loaded stent materials. However, an increase in NiTi porosity may compromise its mechanical properties and cytocompatibility. This study aims to explore the potential of porous NiTi as a vascular drug delivery material and evaluate the impact of porosity on its drug loading and release, mechanical properties, and cytocompatibility. MIM, combined with the powder space-holder method, was used to fabricate porous NiTi alloys with three porosity levels. The mechanical properties of porous NiTi were assessed, as well as the surface cell growth capability. Furthermore, by loading rapamycin nanoparticles onto the surface and within the pores of porous NiTi, we evaluated the in vitro drug release behavior, inhibitory effect on cell proliferation, and inhibition of neointimal hyperplasia in vivo. The results demonstrated that an increase in porosity led to a decrease in the mechanical properties of porous NiTi, including hardness, tensile strength, and elastic modulus, and a decrease in the surface cell growth capability, affecting both cell proliferation and morphology. Concurrently, the loading capacity and release duration of rapamycin were extended with increasing porosity, resulting in enhanced inhibitory effects on cell proliferation in vitro and inhibition of neointimal hyperplasia in vivo. In conclusion, porous NiTi holds promise as a desirable vascular drug delivery material, but a balanced consideration of the influence of porosity on both mechanical properties and cytocompatibility is necessary to achieve an optimal balance among drug-loading and release performance, mechanical properties, and cytocompatibility.

Abstract Image

探索 MIM 制造的多孔镍钛作为血管给药材料的潜力。
采用金属注射成型(MIM)技术制造的多孔镍钛(NiTi)已成为新一代创新的载药支架材料。然而,镍钛孔隙率的增加可能会影响其机械性能和细胞相容性。本研究旨在探索多孔镍钛作为血管给药材料的潜力,并评估孔隙率对其药物负载和释放、机械性能和细胞相容性的影响。研究采用 MIM 结合粉末空间夹持法制备了三种孔隙率水平的多孔镍钛合金。评估了多孔镍钛的机械性能以及表面细胞生长能力。此外,通过在多孔镍钛的表面和孔隙内负载雷帕霉素纳米颗粒,我们评估了体外药物释放行为、对细胞增殖的抑制作用以及对体内新内膜增生的抑制作用。结果表明,孔隙率的增加导致多孔镍钛的力学性能(包括硬度、拉伸强度和弹性模量)下降,表面细胞生长能力下降,细胞增殖和形态都受到影响。同时,雷帕霉素的负载能力和释放时间随着孔隙率的增加而延长,从而增强了对体外细胞增殖的抑制作用和对体内新内膜增生的抑制作用。总之,多孔镍钛有望成为一种理想的血管给药材料,但要在药物负载和释放性能、机械性能和细胞相容性之间达到最佳平衡,就必须平衡考虑孔隙率对机械性能和细胞相容性的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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