Casual associations between brain structure and sarcopenia: A large-scale genetic correlation and mendelian randomization study

IF 7.8 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Aging Cell Pub Date : 2024-06-17 DOI:10.1111/acel.14252
Guang Yang, Wenqing Xie, Bin Li, Guihu Zhao, Jinchen Li, Wenfeng Xiao, Yusheng Li
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Abstract

Sarcopenia presenting a critical challenge in population-aging healthcare. The elucidation of the interplay between brain structure and sarcopenia necessitates further research. The aim of this study is to explore the casual association between brain structure and sarcopenia. Linkage disequilibrium score regression (LDSC) was conducted to estimate the genetic correlations; MR was then performed to explore the causal relationship between Brain imaging-derived phenotypes (BIDPs) and three sarcopenia-related traits: handgrip strength, walking pace, and appendicular lean mass (ALM). The main analyses were conducted using the inverse-variance weighted method. Moreover, weighted median and MR–Egger were conducted as sensitivity analyses. Genetic association between 6.41% of BIDPs and ALM was observed, and 4.68% of BIDPs exhibited causal MR association with handgrip strength, 2.11% of BIDPs were causally associated with walking pace, and 2.04% of BIDPs showed causal association with ALM. Volume of ventromedial hypothalamus was associated with increased odds of handgrip strength (OR: 1.18, 95% CI: 1.02 to 1.37) and ALM (OR: 1.05, 95% CI: 1.01 to 1.09). Mean thickness of G-pariet-inf-Angular was associated with decreased odds of handgrip strength (OR: 0.83, 95% CI: 0.70 to 0.97) and walking pace (OR: 0.97, 95% CI: 0.93 to 0.99). As part of the brain structure forward causally influences sarcopenia, which may provide new perspectives for the prevention of sarcopenia and offer valuable insights for further research on the brain-muscle axis.

Abstract Image

Abstract Image

大脑结构与肌肉疏松症之间的偶然联系:大规模遗传相关性和亡羊补牢随机化研究。
肌肉疏松症是人口老龄化医疗保健领域的一项严峻挑战。阐明大脑结构与 "肌肉疏松症 "之间的相互作用需要进一步的研究。本研究旨在探讨大脑结构与肌肉疏松症之间的偶然联系。研究人员采用连锁不平衡得分回归法(LDSC)估算遗传相关性;然后采用磁共振成像法(MR)探讨脑成像衍生表型(BIDPs)与三种肌肉疏松症相关性状(手握力、步行速度和关节瘦体重(ALM))之间的因果关系。主要分析采用逆方差加权法进行。此外,还进行了加权中位数和 MR-Egger 敏感性分析。结果显示,6.41%的BIDPs与ALM存在遗传关联,4.68%的BIDPs与手握力存在MR因果关联,2.11%的BIDPs与步行速度存在因果关联,2.04%的BIDPs与ALM存在因果关联。下丘脑腹内侧的体积与手握力(OR:1.18,95% CI:1.02-1.37)和ALM(OR:1.05,95% CI:1.01-1.09)的几率增加有关。G-pariet-inf-Angular的平均厚度与手握力(OR:0.83,95% CI:0.70-0.97)和步行速度(OR:0.97,95% CI:0.93-0.99)下降的几率相关。作为大脑结构的一部分,前方会对肌肉疏松症产生因果影响,这可能会为预防肌肉疏松症提供新的视角,并为进一步研究大脑-肌肉轴提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Aging Cell
Aging Cell 生物-老年医学
CiteScore
14.40
自引率
2.60%
发文量
212
审稿时长
8 weeks
期刊介绍: Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.
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