Regional comparison study of Epimedium koreanum using UHPLC-QTOF/MS-based metabolomics approach

IF 2.3 3区农林科学 Q3 FOOD SCIENCE & TECHNOLOGY

Applied Biological Chemistry Pub Date : 2024-06-14 DOI:10.1186/s13765-024-00906-6

Alfan Danny Arbianto, Min Kim, Seon Min Oh, Hyun-Jae Jang, Hyung Won Ryu, Jin-Hyub Paik, Sei-Ryang Oh, Jongmin Ahn

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引用次数: 0

Abstract

The untargeted metabolomics-based molecular networking approach combined with multivariate analysis, proves to be an effective strategy for distinguishing raw materials in herbal medicine according to specific criteria. It exhibits the correlations between chemical constituents and the geographical habitats of plants, providing a valuable tool for ensuring quality control in mass production within the industry. In this study, we conducted a comprehensive investigation of the chemical compositions of Epimedium koreanum Nakai and performed comparative analyses on four extracts collected from distinct regions in South Korea using untargeted metabolomics tools. Through the comprehensive use of UPLC-QTOF/MS analysis and advanced statistical techniques, we elucidated the chemical composition, leading to the identification of key chemical markers. Additionally, the molecular networking analysis revealed distinct clusters of flavonoids and phenolic acids, highlighting the influence of regional factors on the metabolite profiles. These findings offer a promising avenue for enhancing quality control and traceability in the herbal medicine industry, underscoring the important role of geographical variation in the chemical profiles of herbal products.

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基于 UHPLC-QTOF/MS 代谢组学方法的韩国淫羊藿区域比较研究

事实证明，基于非靶向代谢组学的分子网络方法与多元分析相结合，是根据特定标准区分中草药原料的有效策略。它显示了化学成分与植物地理栖息地之间的相关性，为确保行业内大规模生产的质量控制提供了宝贵的工具。在本研究中，我们利用非靶向代谢组学工具对 Epimedium koreanum Nakai 的化学成分进行了全面调查，并对从韩国不同地区采集的四种提取物进行了比较分析。通过综合利用 UPLC-QTOF/MS 分析和先进的统计技术，我们阐明了化学成分，从而确定了关键的化学标记。此外，分子网络分析揭示了黄酮类化合物和酚酸类化合物的独特群集，突出了区域因素对代谢物特征的影响。这些发现为加强中草药行业的质量控制和可追溯性提供了一个前景广阔的途径，同时强调了地理差异在中草药产品化学特征中的重要作用。

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来源期刊

Applied Biological Chemistry Chemistry-Organic Chemistry

CiteScore

5.40

自引率

6.20%

发文量

审稿时长

20 weeks

期刊介绍： Applied Biological Chemistry aims to promote the interchange and dissemination of scientific data among researchers in the field of agricultural and biological chemistry. The journal covers biochemistry and molecular biology, medical and biomaterial science, food science, and environmental science as applied to multidisciplinary agriculture.