Guangle Li , Zheng Dong , Quanzhong Ren , Bingbing Sun , Sijin Liu , Juan Ma , Yi Y. Zuo
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引用次数: 0
Abstract
The regional deposition of inhaled particulate matter (PM) in the respiratory tract determines its biological fate and lung toxicity. While it is widely accepted that the size of PM plays a predominant role in affecting lung deposition, the impact of other physicochemical properties, especially hydrophobicity, remains unclear. This knowledge gap exists, in part, due to the absence of standard methods to characterize the hydrophobicity of PM. Here, we developed a novel nonionic dye partitioning method to quantitatively characterize the hydrophobicity of PM. The use of a nonionic dye, rhodamine B, effectively eliminates experimental artifacts arising from unwanted dye adsorption due to electrostatic interactions, thus significantly improving the accuracy and applicability of the method. Through an intranasal mouse exposure model, we discovered that the lung deposition of four types of PM originated from common anthropogenic sources, including PM2.5, dust, biochar, and carbon black, is mediated by their hydrophobicity. The most hydrophobic PM tends to be trapped in the nasal cavity, whereas the least hydrophobic PM penetrates deep into the alveoli, inducing severe lung inflammation. The hydrophobicity-dependent deposition of PM in the respiratory tract offers novel insights into understanding the acute lung toxicity of inhaled PM and provides a foundation for the design of safer and more efficacious inhalable medicines. Furthermore, the nonionic dye partitioning method shows promise as a user-friendly and cost-effective approach for characterizing the hydrophobicity of PM.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.