A low-cost, portable device for the study of the malaria parasite’s growth inhibition via microwave exposure

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Esteban Rua , Lorena Coronado , Carlos A. Donado Morcillo , Ricardo Correa , Lina Solís , Carmenza Spadafora , Alejandro Von Chong
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Abstract

Recently, a novel method for the growth inhibition of malaria parasites using microwaves was proposed. However, the apparatuses used to demonstrate this method are high-cost and immovable, hindering the progression in this field of research, which is still in its early stages. This paper presents the redesign, construction, and validation of an equivalent system, converting it into a portable and low-cost system, capable of replacing the existing one. The proposed system is mainly composed of an RF generator (MAX2870), an RF amplifier (SKYWORKS 66292-11) and a graphical user interface. Likewise, the RF applicator proposed by the original study was redesigned, resulting in a five-fold improvement in return loss. The obtained results indicate that the proposed system achieves 90% parasite growth inhibition, matching the performance of its counterpart at less than 1% of its cost. These results represent a breakthrough for the creation of smaller, enhanced devices that open new possibilities for an alternative treatment to combat this devastating disease.

Abstract Image

用于研究通过微波照射抑制疟原虫生长的低成本便携式设备
最近,有人提出了一种利用微波抑制疟原虫生长的新方法。然而,用于演示这种方法的仪器成本高且无法移动,阻碍了这一仍处于早期阶段的研究领域的进展。本文介绍了一个等效系统的重新设计、构建和验证,将其转换成一个便携式低成本系统,能够取代现有系统。拟议的系统主要由一个射频发生器(MAX2870)、一个射频放大器(SKYWORKS 66292-11)和一个图形用户界面组成。同样,对原研究提出的射频应用器也进行了重新设计,使回波损耗提高了五倍。研究结果表明,建议的系统能抑制 90% 的寄生虫生长,与同类产品性能相当,而成本却不到其 1%。这些结果标志着在制造更小、更强的设备方面取得了突破性进展,为采用替代疗法防治这种毁灭性疾病提供了新的可能性。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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