Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses

IF 17.6 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2024-06-14 DOI:10.1126/sciimmunol.adp4474

Stephanie A. Ragland, Jonathan C. Kagan

引用次数: 0

Abstract

Single-stranded DNA containing CGT/A motifs binds to the helicase domain of Schlafen 11 (SLFN11) to initiate cell death and cytokine production via SLFN11 ribonuclease activity (see related Research Article by Zhang et al.).

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唤醒沉睡的巨人单链 DNA 与 Schlafen 11 结合，启动先天性免疫反应。

含有 CGT/A motif 的单链 DNA 与 Schlafen 11（SLFN11）的螺旋酶结构域结合，通过 SLFN11 核糖核酸酶的活性启动细胞死亡和细胞因子的产生（见 Zhang 等人的相关研究文章）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.