Switching from cigarettes to IQOS: the relative importance of IQOS-associated reward, reinforcement and abstinence relief.

IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Janet Audrain-McGovern, E Paul Wileyto, Olivia Klapec, Fodie Koita, Andrew A Strasser
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引用次数: 0

Abstract

Introduction: This study investigated whether IQOS, a heated tobacco product, can fully substitute for combustible cigarettes and the factors that promote substitution.

Methods: Adults who smoked cigarettes daily (N=90; 21-65 years) completed a baseline ad-lib smoking period (days 1-5), two laboratory visits (days 6-7) and a 2-week period where they were instructed to switch from smoking cigarettes to using IQOS 3.0 (days 8-21). Mixed-effect modelling estimated the changes in cigarettes per day (CPD) and the percentage of baseline CPD substituted by HeatSticks during the switch period. Predictors included IQOS-associated subjective reward, relative reinforcing value, craving relief and withdrawal relief.

Results: Participants reduced their CPD to about 30% of their baseline smoking rate by the end of the 14-day switch period (p<0001). A lower versus higher reinforcing value of smoking relative to IQOS (RRV; break point <5 vs ≥5) predicted greater reductions in CPD (β=-1.31 (95% CI -2.35 to -0.27) p=0.013). Initially, IQOS use was 72% of the baseline smoking rate (β=71.64 (95% CI 42.79 to 100.48) p<0.0001) and climbed by 0.8% per day (β=0.82 (95% CI 0.01 to 1.64) p=0.05), for an average substitution rate of 83%. The subjective reward of IQOS was the only predictor of a higher substitution rate (β=4.26 (95% CI 1.03 to 7.50) p=0.01).

Conclusions: IQOS fully substituted for cigarettes in ~20% of people who were not immediately interested in quitting smoking while the remainder significantly reduced their smoking. Positive reinforcing effects of IQOS foster use and the transition away from combustible cigarettes.

Trial registration number: NCT05076708.

从香烟转向 IQOS:IQOS 相关奖励、强化和戒断缓解的相对重要性。
导言:本研究调查了加热烟草制品 IQOS 是否能完全替代可燃卷烟以及促进替代的因素:每天吸烟的成年人(人数=90;21-65岁)完成了基线广告吸烟期(第1-5天)、两次实验室访问(第6-7天)和为期两周的从吸烟到使用IQOS 3.0的指导期(第8-21天)。混合效应模型估算了转换期间每天吸烟支数(CPD)的变化以及由 HeatSticks 替代的基线 CPD 的百分比。预测因素包括与 IQOS 相关的主观奖励、相对强化价值、渴求缓解和戒断缓解:结果:在为期 14 天的转换期结束时,参与者的 CPD 下降到其基线吸烟率的 30% 左右(p 结论:IQOS 完全替代了香烟:在约 20% 对戒烟不感兴趣的人中,IQOS 完全替代了香烟,而其余的人则显著减少了吸烟量。IQOS的正强化效应促进了吸烟者使用IQOS并从可燃卷烟过渡:试验注册号:NCT05076708。
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来源期刊
Tobacco Control
Tobacco Control 医学-公共卫生、环境卫生与职业卫生
CiteScore
9.10
自引率
26.90%
发文量
223
审稿时长
6-12 weeks
期刊介绍: Tobacco Control is an international peer-reviewed journal covering the nature and consequences of tobacco use worldwide; tobacco''s effects on population health, the economy, the environment, and society; efforts to prevent and control the global tobacco epidemic through population-level education and policy changes; the ethical dimensions of tobacco control policies; and the activities of the tobacco industry and its allies.
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