Sex- and age-adjusted reference values for dynamic inspiratory constraints during incremental cycle ergometry

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2024-06-11 DOI:10.1016/j.resp.2024.104297

Abed A. Hijleh , Danilo C. Berton , Igor Neder-Serafini , Matthew James , Sandra Vincent , Nicolle Domnik , Devin Phillips , Denis E. O'Donnell , J. Alberto Neder

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Abstract

Activity-related dyspnea in chronic lung disease is centrally related to dynamic (_dyn) inspiratory constraints to tidal volume expansion. Lack of reference values for exertional inspiratory reserve (IR) has limited the yield of cardiopulmonary exercise testing in exposing the underpinnings of this disabling symptom. One hundred fifty apparently healthy subjects (82 males) aged 40–85 underwent incremental cycle ergometry. Based on exercise inspiratory capacity (IC_dyn), we generated centile-based reference values for the following metrics of IR as a function of absolute ventilation: IR_dyn1 ([1-(tidal volume/IC_dyn)] x 100) and IR_dyn2 ([1-(end-inspiratory lung volume/total lung capacity] x 100). IR_dyn1 and IR_dyn2 standards were typically lower in females and older subjects (p<0.05 for sex and age versus ventilation interactions). Low IR_dyn1 and IR_dyn2 significantly predicted the burden of exertional dyspnea in both sexes (p<0.01). Using these sex and age-adjusted limits of reference, the clinician can adequately judge the presence and severity of abnormally low inspiratory reserves in dyspneic subjects undergoing cardiopulmonary exercise testing.

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增量式循环测力法动态吸气约束的性别和年龄调整参考值。

慢性肺部疾病中与活动相关的呼吸困难主要与动态（动态）吸气对潮气量扩张的限制有关。由于缺乏用力吸气储备（IR）的参考值，限制了心肺运动测试在揭示这种致残症状的基础方面的收益。150 名明显健康的受试者（82 名男性），年龄在 40 至 85 岁之间，接受了增量式循环测力。根据运动吸气容量（ICdyn），我们生成了基于百分位数的以下 IR 指标参考值，作为绝对通气量的函数：IRdyn1（[1-（潮气量/ICdyn）] x 100）和 IRdyn2（[1-（吸气末肺活量/总肺活量] x 100）。女性和老年受试者的 IRdyn1 和 IRdyn2 标准通常较低（pdyn1 和 IRdyn2 可显著预测男女受试者的用力呼吸困难负担（p

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.