Sex- and age-adjusted reference values for dynamic inspiratory constraints during incremental cycle ergometry

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-11 DOI:10.1016/j.resp.2024.104297

Abed A. Hijleh , Danilo C. Berton , Igor Neder-Serafini , Matthew James , Sandra Vincent , Nicolle Domnik , Devin Phillips , Denis E. O'Donnell , J. Alberto Neder

{"title":"Sex- and age-adjusted reference values for dynamic inspiratory constraints during incremental cycle ergometry","authors":"Abed A. Hijleh , Danilo C. Berton , Igor Neder-Serafini , Matthew James , Sandra Vincent , Nicolle Domnik , Devin Phillips , Denis E. O'Donnell , J. Alberto Neder","doi":"10.1016/j.resp.2024.104297","DOIUrl":null,"url":null,"abstract":"<div>Activity-related dyspnea in chronic lung disease is centrally related to dynamic (dyn) inspiratory constraints to tidal volume expansion. Lack of reference values for exertional inspiratory reserve (IR) has limited the yield of cardiopulmonary exercise testing in exposing the underpinnings of this disabling symptom. One hundred fifty apparently healthy subjects (82 males) aged 40–85 underwent incremental cycle ergometry. Based on exercise inspiratory capacity (ICdyn), we generated centile-based reference values for the following metrics of IR as a function of absolute ventilation: IRdyn1 ([1-(tidal volume/ICdyn)] x 100) and IRdyn2 ([1-(end-inspiratory lung volume/total lung capacity] x 100). IRdyn1 and IRdyn2 standards were typically lower in females and older subjects (p<0.05 for sex and age versus ventilation interactions). Low IRdyn1 and IRdyn2 significantly predicted the burden of exertional dyspnea in both sexes (p<0.01). Using these sex and age-adjusted limits of reference, the clinician can adequately judge the presence and severity of abnormally low inspiratory reserves in dyspneic subjects undergoing cardiopulmonary exercise testing.</div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1569904824000909","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Activity-related dyspnea in chronic lung disease is centrally related to dynamic (_dyn) inspiratory constraints to tidal volume expansion. Lack of reference values for exertional inspiratory reserve (IR) has limited the yield of cardiopulmonary exercise testing in exposing the underpinnings of this disabling symptom. One hundred fifty apparently healthy subjects (82 males) aged 40–85 underwent incremental cycle ergometry. Based on exercise inspiratory capacity (IC_dyn), we generated centile-based reference values for the following metrics of IR as a function of absolute ventilation: IR_dyn1 ([1-(tidal volume/IC_dyn)] x 100) and IR_dyn2 ([1-(end-inspiratory lung volume/total lung capacity] x 100). IR_dyn1 and IR_dyn2 standards were typically lower in females and older subjects (p<0.05 for sex and age versus ventilation interactions). Low IR_dyn1 and IR_dyn2 significantly predicted the burden of exertional dyspnea in both sexes (p<0.01). Using these sex and age-adjusted limits of reference, the clinician can adequately judge the presence and severity of abnormally low inspiratory reserves in dyspneic subjects undergoing cardiopulmonary exercise testing.

查看原文本刊更多论文

增量式循环测力法动态吸气约束的性别和年龄调整参考值。

慢性肺部疾病中与活动相关的呼吸困难主要与动态（动态）吸气对潮气量扩张的限制有关。由于缺乏用力吸气储备（IR）的参考值，限制了心肺运动测试在揭示这种致残症状的基础方面的收益。150 名明显健康的受试者（82 名男性），年龄在 40 至 85 岁之间，接受了增量式循环测力。根据运动吸气容量（ICdyn），我们生成了基于百分位数的以下 IR 指标参考值，作为绝对通气量的函数：IRdyn1（[1-（潮气量/ICdyn）] x 100）和 IRdyn2（[1-（吸气末肺活量/总肺活量] x 100）。女性和老年受试者的 IRdyn1 和 IRdyn2 标准通常较低（pdyn1 和 IRdyn2 可显著预测男女受试者的用力呼吸困难负担（p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.