The association between dietary inflammatory index and risk of neuromyelitis optica spectrum disorder: a case-control study.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2024-06-13 DOI:10.1080/1028415X.2024.2342154

Leila Darvishi, Vahid Shaygannejad, Marjan Mansourian, Parvane Saneei, Omid Mirmosayyeb, Sayyed Morteza Safavi

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引用次数: 0

Abstract

Background and aim: Neuromyelitis optica spectrum disorder (NMOSD) is a severe and rare inflammatory disease affecting the central nervous system through optic neuritis and transverse myelitis. Present study aimed to investigate the association between dietary inflammatory index (DII) and risk of NMOSD.

Methods: In this case-control study, 30 NMOSD cases and 90 aged matched healthy individuals were recruited. Habitual dietary intakes were assessed by a validated 168-item food frequency questionnaire to calculate the DII score. A multiple adjusted regression was used to determine the odd ratio (OR) of NMOSD across DII tertiles. The Residual method was applied to adjust the energy intake.

Results: Participants in the top of DII tertile were more likely to have NMOSD in the crude model compared to those with the lowest one (OR: 4.18; 95%CI: 1.43-12.21). It was the case when multivariable confounders were considered in adjustment model I (OR: 3.98; 95%CI: 1.34-11.82) and II (OR: 4.43; 95%CI: 1.36-14.38), such that, individuals with a greater DII score had 3.98 and 4.43-time higher risk of NMOSD in model I and II, respectively.

Conclusion: The Present study suggests that greater adherence to a pro-inflammatory diet may be associated with an increased risk of NMOSD.

查看原文本刊更多论文

膳食炎症指数与神经脊髓炎视谱系障碍风险之间的关系：一项病例对照研究。

背景和目的：神经脊髓炎谱系障碍（NMOSD）是一种通过视神经炎和横贯性脊髓炎影响中枢神经系统的严重而罕见的炎症性疾病。本研究旨在探讨膳食炎症指数（DII）与神经脊髓炎视谱系障碍风险之间的关系：在这项病例对照研究中，招募了 30 名 NMOSD 病例和 90 名年龄匹配的健康人。通过有效的 168 项食物频率问卷评估习惯性膳食摄入量，计算出 DII 分数。采用多元调整回归法确定不同 DII 分层中 NMOSD 的奇数比 (OR)。残差法用于调整能量摄入量：结果：在粗略模型中，DII 最高分的参与者比最低分的参与者更有可能患有 NMOSD（OR：4.18；95%CI：1.43-12.21）。当在调整模型 I（OR：3.98；95%CI：1.34-11.82）和 II（OR：4.43；95%CI：1.36-14.38）中考虑到多变量混杂因素时，情况也是如此，因此，在模型 I 和 II 中，DII 分数越高的人患 NMOSD 的风险分别高出 3.98 倍和 4.43 倍：本研究表明，更多地坚持促炎性饮食可能与罹患 NMOSD 的风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.