Impact of endoscopic ultrasound-guided tissue acquisition on prognosis and peritoneal lavage cytology in resectable or borderline resectable pancreatic ductal adenocarcinoma

IF 2.8 2区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Pancreatology Pub Date : 2024-06-06 DOI:10.1016/j.pan.2024.06.001

Motonobu Maruo , Tsukasa Ikeura , Ayaka Takaori , Masatoshi Ikeda , Koh Nakamaru , Takashi Ito , Masataka Masuda , Toshiyuki Mitsuyama , Shinji Nakayama , Masaaki Shimatani , Makoto Takaoka , Nobuhiro Shibata , Shogen Boku , Tomoyo Yasuda , Hidetaka Miyazaki , Kazuki Matsumura , So Yamaki , Daisuke Hashimoto , Sohei Satoi , Makoto Naganuma

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引用次数: 0

Abstract

Objectives

This study aimed to evaluate the clinical impact of preoperative endoscopic ultrasound-guided tissue acquisition (EUS-TA) on the prognosis and incidence of positive peritoneal lavage cytology (PLC) during laparotomy or staging laparoscopy in patients with resectable (R) or borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC).

Methods

We retrospectively collected data from patients diagnosed with body and tail PDAC with/without EUS-TA at our hospital from January 2006 to December 2021.

Results

To examine the effect of EUS-TA on prognosis, 153 patients (122 in the EUS-TA group, 31 in the non-EUS-TA group) were analyzed. There was no significant difference in overall survival between the EUS-TA and non-EUS-TA groups after PDAC resection (P = 0.777). In univariate and multivariate analysis, preoperative EUS-TA was not identified as an independent factor related to overall survival after pancreatectomy [hazard ratio 0.96, 95 % confidence interval (CI) 0.54–1.70, P = 0.897]. Next, to examine the direct influence of EUS-TA on the results of PLC, 114 patients (83 in the EUS-TA group and 31 in the non-EUS-TA group) were analyzed. Preoperative EUS-TA was not statistically associated with positive PLC (odds ratio 0.73, 95 % CI 0.25–2.20, P = 0.583). After propensity score matching, overall survival and positive PLC were the same in both groups.

Conclusions

EUS-TA had no negative impact on postoperative survival and PLC-positive rates in R/BR PDAC.

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内镜超声引导下组织采集对可切除或边缘可切除胰腺导管腺癌预后和腹腔灌洗细胞学的影响

研究目的本研究旨在评估术前内镜超声引导下组织采集（EUS-TA）对可切除（R）或边缘可切除（BR）胰腺导管腺癌（PDAC）患者的预后和腹腔灌洗细胞学（PLC）阳性发生率的临床影响：我们回顾性地收集了2006年1月至2021年12月期间在我院确诊的体部和尾部PDAC患者接受/未接受EUS-TA检查的数据：为了研究 EUS-TA 对预后的影响，我们对 153 例患者（EUS-TA 组 122 例，非 EUS-TA 组 31 例）进行了分析。PDAC切除术后，EUS-TA组和非EUS-TA组的总生存率无明显差异（P = 0.777）。在单变量和多变量分析中，术前 EUS-TA 未被确定为与胰腺切除术后总生存率相关的独立因素[危险比 0.96，95 % 置信区间 (CI) 0.54-1.70，P = 0.897]。接下来，为了研究 EUS-TA 对 PLC 结果的直接影响，我们对 114 例患者（EUS-TA 组 83 例，非 EUS-TA 组 31 例）进行了分析。术前 EUS-TA 与 PLC 阳性无统计学关联（几率比 0.73，95 % CI 0.25-2.20，P = 0.583）。经过倾向评分匹配后，两组患者的总生存率和PLC阳性率相同：结论：EUS-TA对R/BR PDAC患者的术后生存率和PLC阳性率没有负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pancreatology 医学-胃肠肝病学

CiteScore

7.20

自引率

5.60%

发文量

194

审稿时长

44 days

期刊介绍： Pancreatology is the official journal of the International Association of Pancreatology (IAP), the European Pancreatic Club (EPC) and several national societies and study groups around the world. Dedicated to the understanding and treatment of exocrine as well as endocrine pancreatic disease, this multidisciplinary periodical publishes original basic, translational and clinical pancreatic research from a range of fields including gastroenterology, oncology, surgery, pharmacology, cellular and molecular biology as well as endocrinology, immunology and epidemiology. Readers can expect to gain new insights into pancreatic physiology and into the pathogenesis, diagnosis, therapeutic approaches and prognosis of pancreatic diseases. The journal features original articles, case reports, consensus guidelines and topical, cutting edge reviews, thus representing a source of valuable, novel information for clinical and basic researchers alike.