TAF15 downregulation contributes to the benefits of physical training on dendritic spines and working memory in aged mice

IF 7.8 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Aging Cell Pub Date : 2024-06-14 DOI:10.1111/acel.14244
Yun He, Benju Liu, Fu-Yuan Yang, Qun Yang, Benke Xu, Lian Liu, Yuncai Chen
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Abstract

Moderate physical training has been shown to hinder age-related memory decline. While the benefits of physical training on hippocampal memory function are well-documented, little is known about its impact on working memory, which is linked to the prelimbic cortex (PrL), one major subdivision of the prefrontal cortex. Here, we examined the effects of physical training on spatial working memory in a well-established animal model of physical training, starting at 16 months of age and continuing for 5 months (running wheel 1 h/day and 5 days/week). This training strategy improved spatial working memory in aged mice (22-month-old), which was accompanied by an increased spine density and a lower TAF15 expression in the PrL. Specifically, physical training affected both thin and mushroom-type spines on PrL pyramidal cells, and prevented age-related loss of spines on selective segments of apical dendritic branches. Correlation analysis revealed that increased TAF15-expression was detrimental to the dendritic spines. However, physical training downregulated TAF15 expression in the PrL, preserving the dendritic spines on PrL pyramidal cells and improving working memory in trained aged mice. When TAF15 was overexpressed in the PrL via a viral approach, the benefits of physical training on the dendritic spines and working memory were abolished. These data suggest that physical training at a moderate pace might downregulate TAF15 expression in the PrL, which favors the dendritic spines on PrL pyramidal cells, thereby improving spatial working memory.

Abstract Image

Abstract Image

TAF15下调有助于体育训练对老年小鼠树突棘和工作记忆的益处。
适度的体育训练已被证明可以阻止与年龄有关的记忆力衰退。虽然体能训练对海马记忆功能的益处已得到充分证实,但人们对体能训练对工作记忆的影响却知之甚少,而工作记忆与前额叶皮质(PrL)有关,前额叶皮质是前额叶皮质的一个主要分支。在这里,我们研究了体能训练对空间工作记忆的影响,这是一种成熟的体能训练动物模型,从 16 个月大开始,持续 5 个月(跑步轮每天 1 小时,每周 5 天)。这种训练策略改善了老年小鼠(22 个月大)的空间工作记忆,同时增加了脊柱密度,降低了 PrL 中 TAF15 的表达。具体来说,物理训练影响了PrL锥体细胞上的细刺和蘑菇型棘突,并防止了与年龄有关的尖突分支选择性片段上棘突的丧失。相关分析表明,TAF15表达的增加对树突棘不利。然而,体育训练会降低TAF15在PrL中的表达,从而保护PrL锥体细胞上的树突棘,并改善受训老年小鼠的工作记忆。当通过病毒方法在PrL中过表达TAF15时,体育训练对树突棘和工作记忆的益处就会消失。这些数据表明,适度的体育训练可能会下调TAF15在PrL中的表达,而TAF15的表达有利于PrL锥体细胞上的树突棘,从而改善空间工作记忆。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Aging Cell
Aging Cell 生物-老年医学
CiteScore
14.40
自引率
2.60%
发文量
212
审稿时长
8 weeks
期刊介绍: Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.
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