Habenular volume changes after venlafaxine treatment in patients with major depression.

IF 5 3区医学 Q1 CLINICAL NEUROLOGY

Psychiatry and Clinical Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-12 DOI:10.1111/pcn.13684

Josselin Etienne, Alexandre Boutigny, Denis J David, Eric Deflesselle, Florence Gressier, Laurent Becquemont, Emmanuelle Corruble, Romain Colle

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Abstract

Background: Habenula, a hub brain region controlling monoaminergic brain center, has been implicated in major depressive disorder (MDD) and as a possible target of antidepressant response. Nevertheless, the effect of antidepressant drug treatment on habenular volumes remains unknown. The objective of the present research was to study habenular volume change after antidepressant treatment in patients with MDD, and assess whether it is associated with clinical improvement.

Methods: Fifty patients with a current major depressive episode (MDE) in the context of MDD, and antidepressant-free for at least 1 month, were assessed for habenula volume (3T MRI with manual segmentation) before and after a 3 months sequence of venlafaxine antidepressant treatment.

Results: A 2.3% significant increase in total habenular volume (absolute volume: P = 0.0013; relative volume: P = 0.0055) and a 3.3% significant increase in left habenular volume (absolute volume: P = 0.00080; relative volume: P = 0.0028) were observed. A significant greater variation was observed in male patients (4.8%) compared to female patients. No association was observed between habenular volume changes and response and remission. Some habenula volume changes were associated with improvement of olfactory pleasantness.

Conclusion: Habenular volumes increased after 3 months of venlafaxine treatment in depressed patients. Further studies should assess whether cell proliferation and density or dendritic structure variations are implied in these volume changes.

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重度抑郁症患者接受文拉法辛治疗后血容量的变化。

背景：哈伯脑是控制单胺能大脑中枢的中枢脑区，与重度抑郁症（MDD）有关，也可能是抗抑郁药物反应的靶点。然而，抗抑郁药物治疗对哈伯脑体积的影响仍然未知。本研究的目的是研究重度抑郁症患者在接受抗抑郁药物治疗后的瓣膜体积变化，并评估其是否与临床改善相关：方法：在文拉法辛抗抑郁治疗 3 个月前后，对 50 名目前有重度抑郁发作（MDE）且至少 1 个月未服用抗抑郁药物的患者进行哈文脑体积评估（3T MRI，手动分割）：结果：观察结果显示，脑叶总体积显著增加了 2.3%（绝对体积：P = 0.0013；相对体积：P = 0.0055），左脑叶体积显著增加了 3.3%（绝对体积：P = 0.00080；相对体积：P = 0.0028）。与女性患者相比，男性患者的变化明显更大（4.8%）。没有观察到瓣膜体积变化与反应和缓解之间存在关联。一些脑叶体积的变化与嗅觉舒适度的改善有关：结论：抑郁症患者在接受文拉法辛治疗3个月后，脑泡体积有所增加。进一步的研究应评估这些体积变化是否意味着细胞增殖和密度或树突结构的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry and Clinical Neurosciences 医学-精神病学

CiteScore

7.40

自引率

4.20%

发文量

181

审稿时长

6-12 weeks

期刊介绍： PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author